Results 61 to 70 of about 2,733,297 (314)

Classification of facial nerve aberration in congenital malformation of middle ear: Implications for surgery of hearing restoration

Journal of Otology, 2018
Objectives: Facial nerve aberration is the most troublesome situation in congenital malformations of middle ear. The aim of our study is to investigate its imaging and clinical features as well as relevant choice of surgical techniques for hearing ...
Jin Hao, Liping Xu, Shuling Li, Xinxing Fu, Shouqin Zhao   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Local versus general anesthesia for transcatheter aortic valve implantation (TAVR)- systematic review and meta-analysis [PDF]

, 2014
The hypothesis of this study was that local anesthesia with monitored anesthesia care (MAC) is not harmful in comparison to general anesthesia (GA) for patients undergoing Transcatheter Aortic Valve Implantation (TAVR).TAVR is a rapidly spreading ...
Webb, J, Reinthaler, M, Georg M Fröhlich, Marco Roffi, Olaf Wendler, Nevil Hutchinson, Markus Reinthaler, Duolao Wang, David Hildick-Smith, Wang, D, Hutchinson, N, Fröhlich, GM, John Webb, Pascal Meier, Alexandra J Lansky, Wendler, O, Hildick-Smith, D, Stefan Toggweiler, Lansky, AJ, Roffi, M, Meier, P, Toggweiler, S, Roffi, Marco, Wendler, Olaf, Webb, John, Lansky, Alexandra J, Wang, Duolao, Meier, Pascal, Hildick-Smith, David, Hutchinson, Nevil, Toggweiler, Stefan, Fröhlich, Georg M, Reinthaler, Markus   +32 more
core   +2 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Study Protocol: Evaluating the Effectiveness of Variable Embryo Transfer Compared to Endometrial Receptivity Analysis in Improving Implantation and Pregnancy Outcomes in Patients with Recurrent Implantation Failure

Journal of Pharmacy and Bioallied Sciences
Background: Infertility is an inability to achieve pregnancy after 12 or more months of unprotected sexual intercourse, with recurrent implantation failure being a major challenge in assisted reproductive techniques (ARTs).
Tejaswini Wadhe, Akash More, Namrata Choudhary   +2 more
doaj   +1 more source

Miss Ellen Terry As "Margaret" / [fotografiert von:] Window & Grove [PDF]

, 1880
MISS ELLEN TERRY AS "MARGARET" / [FOTOGRAFIERT VON:] WINDOW & GROVE [Künstlerfotografien zum Faustthema : Darsteller und Darstellerinnen des "Faust"] (-) Miss Ellen Terry As "Margaret" / [fotografiert von:] Window & Grove (143) (1 ...
Window, Grove
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

The serum level of E2 and P4 in Group A , C and SC in the window of implantation.

, 2013
The serum level of E2 and P4 in Group A , C and SC in the window of implantation.
Ning Wang (108353), Linlin Geng (329066), Shucheng Zhang (300997), Bin He (75597), Jiedong Wang (300998)   +4 more
core   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Morphological evidence for the `implantation window' in human luminal endometrium [PDF]

Human Reproduction, 1999
Endometrial tissue was taken from 21 normal fertile women (aged 18-40 years) between 4 and 13 days after the luteinizing hormone (LH) surge. Systematic random samples of luminal epithelium were taken for both light and electron microscopy and examined morphometrically. Throughout the luteal phase there were remarkably few changes in the volume fraction
S A, Sarani, M, Ghaffari-Novin, M A, Warren, P, Dockery, I D, Cooke   +4 more
openaire   +2 more sources