Results 101 to 110 of about 4,485,274 (315)

Study of cluster formation in a model of nanotechnology development

Latin American Journal of Solids and Structures
Mathematical model describing the development of science (nanotechnology) in Russian Federation is proposed. Results of numerical simulations are presented and discussed in the context of socio-economical interpretation.
Artem Balyakin, Anna Domnich, Vladimir Zhulego, Anna Ivanova   +3 more
doaj   +1 more source

Erlotinib and gefitinib for treating non-small cell lung cancer that has progressed following prior chemotherapy (review of NICE technology appraisals 162 and 175): a systematic review and economic evaluation

Health Technology Assessment, 2015
Background: Lung cancer is the second most diagnosed cancer in the UK. Over 70% of lung cancers are non-small cell lung cancers (NSCLCs). Patients with stage III or IV NSCLC may be offered treatment to improve survival, disease control and quality of ...
Janette Greenhalgh, Adrian Bagust, Angela Boland, Kerry Dwan, Sophie Beale, Juliet Hockenhull, Christine Proudlove, Yenal Dundar, Marty Richardson, Rumona Dickson, Anna Mullard, Ernie Marshall   +11 more
doaj   +1 more source

Lean Enterprise Transformation in VA: a national evaluation framework and study protocol

BMC Health Services Research, 2019
Background The goal of Lean Enterprise Transformation (LET) is to go beyond simply using Lean tools and instead embed Lean principles and practices in the system so that it becomes a fundamental, collective mindset of the entire enterprise.
Anita A. Vashi, Barbara Lerner, Tracy H. Urech, Steven M. Asch, Martin P. Charns   +4 more
doaj   +1 more source

Never the twain shall meet? - a comparison of implementation science and policy implementation research [PDF]

, 2013
Background: Many of society's health problems require research-based knowledge acted on by healthcare practitioners together with implementation of political measures from governmental agencies.
Cairney, Paul,, Ståhl, Christian,, Nilsen, Per, Christian Ståhl, Roback, Kerstin, Paul Cairney, Roback, Kerstin,, Nilsen, Per,, Stahl, Christian, Kerstin Roback, Per Nilsen, Cairney, Paul   +11 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Embedding consumer and community involvement in antenatal healthcare research: A methodological approach and perspectives of culturally and linguistically diverse women in Australia

Research Involvement and Engagement
Background Consumer and Community Involvement (CCI) in healthcare research ensures that the needs of target populations are met through active collaboration between consumers, communities, and researchers. For culturally and linguistically diverse (CALD)
Bonnie R. Brammall, Rebecca L. Madill, Rhonda M. Garad, Bao N. Nguyen, Nitya Nagesh, Cheryce L. Harrison   +5 more
doaj   +1 more source

Effectiveness and safety of natural mineral water rich in magnesium and sulfates for the intestinal function

Медицинский совет, 2016
A randomized, placebo-controlled, double-blind trialObjective. The present randomized placebo-controlled double-blind trial was conducted to examine whether natural mineral water with a high content of magnesium sulfate and sodium sulfate (Donat Mg ...
Gordana Bote, Alyaz Chokh, Annegret Auinger   +2 more
doaj   +1 more source

Implementation in adaptive better-response dynamics [PDF]

, 2007
We study the classic implementation problem under the behavioral assumption that agents myopically adjust their actions in the direction of better-responses within a given institution.
Roberto Serrano, Serrano, Roberto, Cabrales, Antonio, Antonio Cabrales, Cabrales Goitia, Antonio   +4 more
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