Results 81 to 90 of about 4,485,274 (315)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Strategy for soil and water management in the Thames River Basin

, 1982
This report presents a summary of the Thames River Implementation Committee program and discusses the key program recommendations related to policy, community education, land use management and conservation practices.Ontario Ministry of the ...
Thames River Implementation Committee
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

What incentives influence employers to engage in workplace health interventions?

BMC Public Health, 2016
Background To achieve a sustainable working life it is important to know more about what could encourage employers to increase the use of preventive and health promotive interventions.
Camilla Martinsson, Malin Lohela-Karlsson, Lydia Kwak, Gunnar Bergström, Therese Hellman   +4 more
doaj   +1 more source

Progress report 2: A report on the implementation aspects of the Thames River Basin water management study

, 1980
This second TRIC Progress Report outlines the revised status of each of the recommendations since the time of the first Progress Report, provides an overview of the 1980/81 work program, and discusses the work plan for 1981/82.Ontario Ministry of the ...
Thames River Implementation Committee
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

iSPARC 2024 Annual Report to the Massachusetts Department of Mental Health

In fiscal year 2024, iSPARC continued to leverage DMH’s investment to rapidly translate research findings into their implementation within best practices for individuals with lived experience, their families, and the providers who serve them across the ...
Implementation Science and Practice Advances Research Center
core   +1 more source

Robust implementation under alternative information structures [PDF]

, 1995
Nash Implementation, Incomplete information, Local information, CF2, DF1, D82,
Ignacio Ortuño-Ortin, Ortuño, Ignacio, Corchón, Luis C., Luis Corchon   +3 more
core   +1 more source

Implementing Anchoring [PDF]

, 2006
In an earlier paper we introduced Anchoring, a new approach for handling indeterminate location in a spatial information system. Here we develop it further, showing how Anchoring can be made to work in real systems. In particular, we specify a new kind of locational component for a spatial data model.
James Hood, Antony Galton
openaire   +1 more source