Results 81 to 90 of about 4,047,294 (234)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Implementing a WTO agreement on trade facilitation : what makes sense ? [PDF]

Contrary to the prevailing view that the Doha negotiations have achieved little, the authors find that on trade facilitation much progress has been made.
Finger, J. Michael, Wilson, John S.
core  

Trade facilitation and paperless trade implementation survey 2015 : Europe and Central Asia Report [PDF]

, 2016
The Global Survey on Trade Facilitation and Paperless Trade has been conducted by the United Nations Regional Commissions (UNECA, UNECE, UNECLAC, UNESCAP and UNESCWA), in collaboration with the OECD and UNCTAD in order to collect relevant data and ...
UN.ESCAP, UN.ECE
core   +1 more source

Using the IFASIS (Inventory of Factors Affecting Successful Implementation and Sustainment) to advance context-specific and generalizable knowledge of implementation determinants: case study of a digital contingency management platform

Implementation Science Communications
Background Contingency management (CM) is the most effective treatment for stimulant use disorder but is underutilized by opioid treatment programs (OTPs) despite the high prevalence of stimulant use in this setting.
Andrea Jakubowski, Briana Patrick, Kira DiClemente-Bosco, Sarah Salino, Kelli Scott, Sara Becker   +5 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Employing external facilitation to implement cognitive behavioral therapy in VA clinics: a pilot study

Implementation Science, 2010
Background Although for more than a decade healthcare systems have attempted to provide evidence-based mental health treatments, the availability and use of psychotherapies remains low.
Blevins Dean, Sullivan Greer, Kauth Michael R, Cully Jeffrey A, Landes Reid D, Said Qayyim, Teasdale Thomas A   +6 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Studies in Trade and Investment: The Development Impact of Information Technology in Trade Facilitation [PDF]

It is important to lay out a framework for understanding how trade facilitation (TF) affects the movement of goods, and where information (IT) fits in. This relationship, in turn, sets the stage for locating small and medium-sized enterprises (SMEs) in ...
Florian A. Alburo
core   +2 more sources