Results 71 to 80 of about 4,047,294 (234)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Facilitation as an effective strategy to reduce excessive antibiotic prophylaxis in Children’s hospitals: A stepped-wedge cluster randomized controlled trial

Implementation Science
Background Excessive use of postoperative prophylactic antibiotics in children’s hospitals is a significant public health concern, leading to increased risks of infections like Clostridioides difficile, multidrug-resistant organisms, and unnecessary ...
Virginia McKay, Sara Malone, Emmanuel Tetteh, Jacqueline Saito, Shawn Rangel, Kelly Bono, Jade Tao, Jingxia Liu, Harry Obeng, Andrew Atkinson, Jason G. Newland   +10 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Testing implementation facilitation of a primary care-based collaborative care clinical program using a hybrid type III interrupted time series design: a study protocol

Implementation Science, 2018
Background Dissemination of evidence-based practices that can reduce morbidity and mortality is important to combat the growing opioid overdose crisis in the USA.
Amanda M. Midboe, Steve Martino, Sarah L. Krein, Joseph W. Frank, Jacob T. Painter, Michael Chandler, Allison Schroeder, Brenda T. Fenton, Lara Troszak, Taryn Erhardt, Robert D. Kerns, William C. Becker   +11 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Trade facilitation and paperless trade implementation survey 2017 : Sub-Regional Notes - North and Central Asia [PDF]

, 2017
This note is part of a new global effort by all United Nations Regional Commissions (UNRCs), in cooperation with other international organizations, to provide reliable and sufficiently detailed data on the implementation of trade facilitation in ...
UN.ESCAP, United Nations Network of Experts for Paperless Trade and Transport in Asia and the Pacific (UNNExT)   +1 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Evaluating a virtual facilitation workshop with antimicrobial stewardship teams within a cluster randomized stepped-wedge trial

BMC Health Services Research
Background Antimicrobial stewardship programs (ASP) often function naturally as facilitators within clinical hospital settings, by working with individuals and teams to reduce unnecessary antibiotics.
Sara Malone, Kelly Bono, Jacqueline M. Saito, Shawn Rangel, Jingxia Liu, Jason G. Newland, Virginia McKay   +6 more
doaj   +1 more source

Facilitated interprofessional implementation of a physical rehabilitation guideline for stroke in inpatient settings: process evaluation of a cluster randomized trial

Implementation Science, 2017
Background The Stroke Canada Optimization of Rehabilitation by Evidence-Implementation Trial (SCORE-IT) showed that a facilitated knowledge translation (KT) approach to implementing a stroke rehabilitation guideline was more likely than passive ...
Nancy M. Salbach, Sharon Wood-Dauphinee, Johanne Desrosiers, Janice J. Eng, Ian D. Graham, Susan B. Jaglal, Nicol Korner-Bitensky, Marilyn MacKay-Lyons, Nancy E. Mayo, Carol L. Richards, Robert W. Teasell, Merrick Zwarenstein, Mark T. Bayley, on behalf of the Stroke Canada Optimization of Rehabilitation By Evidence – Implementation Trial (SCORE-IT) Team   +13 more
doaj   +1 more source