Facilitators and barriers to implementing clinical care pathways [PDF]
The promotion of care pathways in the recent Governmental health policy reports of Lord Darzi is likely to increase efforts to promote the use of care pathways in the NHS. Evidence on the process of pathway implementation, however, is sparse and variations in how organisations go about the implementation process are likely to be large.
Evans, Sara +3 more
openaire +4 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Trade facilitation and paperless trade implementation in Asia and the Pacific : regional report 2017 [PDF]
Reducing trade costs is essential for developing economies to participate in international production networks and effectively use trade as an engine of growth and sustainable development.
UN.ESCAP
core +1 more source
Background Post-9/11 veterans who enroll in VA health care frequently present with suicidal ideation and/or recent suicidal behavior. Most of these veterans are not screened on their day of enrollment and their risk goes undetected. Screening for suicide
James O. E. Pittman +10 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Trade facilitation and paperless trade implementation survey 2017 : Sub-Regional Notes - South and South-West Asia [PDF]
This note is part of a new global effort by all United Nations Regional Commissions (UNRCs), in cooperation with other international organizations, to provide reliable and sufficiently detailed data on the implementation of trade facilitation in general -
UN.ESCAP +1 more
core +1 more source
Implementation strategies, and barriers and facilitators for implementation of physical activity at work: a scoping review [PDF]
AbstractBackgroundInactivity and sedentary lifestyle have led experts to recommend an increase in structured, workplace-based physical activity (PA) initiatives. Previous studies on workplace-based PA have only shown moderate and short-term effects. This has been attributed to the lack of clear implementation strategies and understanding of factors ...
Anne Garne-Dalgaard +3 more
openaire +3 more sources
Prospecting the protein design landscape
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Trade facilitation and paperless trade implementation survey 2017 : Sub-Regional Notes - East and North-East Asia [PDF]
This note is part of a new global effort by all United Nations Regional Commissions (UNRCs), in cooperation with other international organizations, to provide reliable and sufficiently detailed data on the implementation of trade facilitation in ...
UN.ESCAP
core +1 more source

