Results 111 to 120 of about 7,716,939 (299)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Long-term Implementation and Clinical Outcomes: Nutrition Literacy Program for Oral Health Promotion

Introduction: Nutrition literacy represents a critical determinant of oral health outcomes. Guided by Social Cognitive Theory and the Nutrition Literacy Skills Framework, this study evaluated the implementation and effectiveness of a nutrition literacy ...
Chollada Sorasak, Worayuth Nak-Ai, Mansuang Wongsapai, Choosak Yuennan   +3 more
core   +1 more source

Implementation frameworks, strategies and outcomes used in peripheral intravenous catheter studies: A systematic review

, 2023
Aims: The aim of this study was to critically evaluate implementation frameworks, strategies and/or outcomes used to optimise peripheral intravenous catheter (PIVC) care and/or promote guideline adherence.
Marsh, Nicole, Justin Clark, Xu, Hui Grace, Bronwyn Griffin, Nicole Marsh, Claire M. Rickard, Amanda J. Ullman, Ullman, Amanda J, Clark, Justin, Griffin, Bronwyn, Tobiano, Georgia, Hui (Grace) Xu, Georgia Tobiano, Rickard, Claire M, Samantha Keogh, Keogh, Samantha   +15 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

What validated instruments, that measure implementation outcomes, are suitable for use in the Paediatric Intensive Care Unit (PICU) setting? A systematic review of systematic reviews [PDF]

Background/aimsThe measurement of implementation outcomes can establish the success of implementing evidence into practice. However, implementation outcomes are seldom measured in acute healthcare settings, such as Paediatric Intensive Care Units (PICU),
Timmons, Stephen, Dodds, Elizabeth, Manning, Joseph C, Redsell, Sarah   +3 more
core  

iSPARC 2020 Annual Report to the Massachusetts Department of Mental Health

, 2020
In Fiscal Year 2020 (FY20), iSPARC continued to leverage DMH’s investment to rapidly translate findings from mental health services and implementation research into best practices for individuals with lived experience, their families, and the providers ...
Implementation Science and Practice Advances Research Center
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

A pragmatic cluster randomised trial evaluating three implementation interventions [PDF]

, 2012
Background Implementation research is concerned with bridging the gap between evidence and practice through the study of methods to promote the uptake of research into routine practice.
Allen, Claire, Seers, Kate, Hawkes, C. M., Strunin, Leo, Seers, K., Rycroft-Malone, J., Strunin, L., Rycroft-Malone, Jo, Crichton, N., Hawkes, C.A., Chandler, J., Bullock, Ian, Allen, C., Chandler, Jackie, Crichton, Nicola, Bullock, I.   +15 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source