Results 131 to 140 of about 7,716,939 (299)

Evaluation Frameworks in Implementation Science: A Review of Key Features and Practical Applications

Xiehe Yixue Zazhi
Implementation evaluation frameworks are essential tools in implementation science for assessing the quality and effectiveness of evidence-based interventions.
Taylor Lauren, LIANG Huijuan, CHEN Cong, YANG Xiaomeng, XU Dong   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Definitions of implementation outcomes.

, 2019
Definitions of implementation outcomes.
Marinda Roelofse (7871552), Katherine Sorsdahl (366817), Megan Malan (5506475), Sa’ad Lahri (7871555), Dan J. Stein (7439063), Bronwyn Myers (2187313), Tracey Naledi (4972930), Claire van der Westhuizen (7871549)   +7 more
core   +1 more source

Implementation outcomes of a CBT-based psychosocial intervention for gang-recruitment-vulnerable youth in Medellín: A qualitative study of novice provider experiences

Cambridge Prisms: Global Mental Health
This study examines the implementation outcomes of Parceros Creadores, a municipal government program in Medellín, Colombia, which deployed novice psychologists to deliver a cognitive-behavioral therapy (CBT) protocol to youth aged 14–28 years in ...
Mariantonia Lemos, Santiago Tobón, Gabriela Algarín, Martín Vanegas-Arias   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Defining Implementation - A process or an outcome? [PDF]

, 2019
The term implementation is widely used, not only in stress interventions, but also in related fields. Particular with the emergence of implementation science, the popularity of the term increased. However, in stress preventive interventions, the term implementation is continuously used without a clear definition and there appears to be several distinct
Ipsen, Christine; id_orcid 0000-0002-2394-5571, Poulsen, Signe, Jonsdottir, Selma, Edwards, Kasper; id_orcid 0000-0002-6328-1765   +3 more
openaire  

FHWA research and development implementation catalog.

Cover title.Mode of access ...
United States. Federal Highway Administration. Implementation Division.
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source