Results 121 to 130 of about 7,716,939 (299)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

MSafe Implementation Committee Report

, 2021
As part of the President's Campus Safety Initiative, the MSafe Implementation Committee was charged by President Gabel to review Dr. Alexander’s report and provide recommendations on further action.MSafe Implementation Committee. (2021).
MSafe Implementation Committee
core  

Implementation of singing groups for postnatal depression: experiences of participants and professional stakeholders in the SHAPER-PND randomised controlled trial

Frontiers in Health Services
BackgroundThere is a rapidly growing evidence base for the effectiveness of creative health interventions in improving mental health, but few studies have explored implementation and scaling of these interventions.
Emeline Han, Rachel Davis, Rachel Davis, Tayana Soukup, Tayana Soukup, Alexandra Bradbury, Julie Williams, Maria Baldellou Lopez, Lorna Greenwood, Rebecca Bind, Carolina Estevao, Tim Osborn, Hannah Dye, Kristi Priestley, Lavinia Rebecchini, Katie Hazelgrove, Manomani Manoharan, Anthony Woods, Nikki Crane, Andy Healey, Paola Dazzan, Nick Sevdalis, Carmine M. Pariante, Daisy Fancourt, Ioannis Bakolis, Ioannis Bakolis, Alexandra Burton   +26 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Medical‐Legal Partnerships as Structural Interventions: Integrating Implementation Science and Community‐Engaged Research to Advance HIV Care

Journal of the International AIDS Society
Introduction People living with HIV (PLWH) often face health‐harming legal needs (HHLNs), including housing instability, discrimination, immigration concerns, benefit denials and interpersonal violence, which can undermine engagement in care and health ...
Omar Martinez, Edda Santiago Rodriguez, Guillermo Prado, Kathryn M. Nowotny, Robin Davison, Cui Yang, Samantha Morton, Ashley French, Souhail Malave‐Rivera, Carlos E. Rodriguez‐Diaz, Florence Momplaisir, Elena Cyrus, Mallory O. Johnson, Miguel Munoz‐Laboy   +13 more
doaj   +1 more source

Acceptability, Feasibility and Appropriateness of Care of Patients with Depression at Health and Wellness Centre in a District of India

Preventive Medicine: Research & Reviews
Objective: To study implementation of mental health services delivery with depression as tracer condition through Health and Wellness Centres (HWCs) under Ayushman Bharat programme in India. Materials and Methods: Mixed methods approach.
Sourabh Saxena, Anant Bhan, William Fleming, Abhishek Singh, Deepak Tugnawat   +4 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Implementing Outcome Measures in Palliative Care [PDF]

Journal of Palliative Medicine, 2018
Guo, Ping, Gao, Wei, Higginson, Irene J., Harding, Richard   +3 more
openaire   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source