Results 91 to 100 of about 669,720 (312)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Implementation of a canonical phase measurement with quantum feedback

, 2019
Much of modern metrology and communication technology encodes information in electromagnetic waves, typically as an amplitude or phase. While current hardware can perform near-ideal measurements of photon number or field amplitude, to date no device ...
Leigh S. Martin, Shay Hacohen-Gourgy, Wiseman, Howard M, Wiseman, Howard M., William P. Livingston, Howard M. Wiseman, Irfan Siddiqi, Livingston, William P., Livingston, William P, Martin, Leigh S., Hacohen-Gourgy, Shay, Martin, Leigh S, Siddiqi, Irfan   +12 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Implementation strategies and stakeholders responsible by implementation phase.

, 2019
Implementation strategies and stakeholders responsible by implementation phase.
Marinda Roelofse (7871552), Katherine Sorsdahl (366817), Megan Malan (5506475), Sa’ad Lahri (7871555), Dan J. Stein (7439063), Bronwyn Myers (2187313), Tracey Naledi (4972930), Claire van der Westhuizen (7871549)   +7 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Implementing a Hybrid Graduate Program: Lessons Learned One Year Later [PDF]

Journal of Systemics, Cybernetics and Informatics, 2016
Development of any graduate program is an extensive and timely process. Once the development phase is complete the program continues into the implementation phase.
Ronda Sturgill, Jacob Wilson, J. C. Andersen   +2 more
doaj  

Surveillance of antimicrobial resistance in the United Arab Emirates: the early implementation phase. [PDF]

Front Public Health, 2023
Thomsen J, Abdulrazzaq NM, AlRand H, UAE AMR Surveillance Consortium.   +3 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Phase-level synchronization for physical-layer network coding [PDF]

, 2012
Physical-layer network coding (PNC) brings throughput improvement for wireless networks. However, its synchronization requirement is widely recognized as an obstacle to its implementation.
Song, Q, Abbas Jamalipour, Huang, Y, Qingyang Song, Shiqiang Wang, Wang, S, Jamalipour, A, Yang Huang   +7 more
core   +1 more source