Results 71 to 80 of about 2,649,115 (298)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Data driven optimal filtering for phase and frequency of noisy oscillations: application to vortex flowmetering

, 2003
A new method for extracting the phase of oscillations from noisy time series is proposed. To obtain the phase, the signal is filtered in such a way that the filter output has minimal relative variation in the amplitude (MIRVA) over all filters with ...
A. G. Rossberg, A. Stefanovska, A. Stefanovska, A.S. Pikovsky, B. Blasius, B. Boashash, B. Schack, D. Gabor, D.J. DeShazer, D.S. Broomhead, H. Gasquet, J. Bhattacharya, J. Bhattacharya, J. Theiler, J. Timmer, J.-P. Lachaux, J.E. Amadi-Echendy, J.Y. Chen, K. Bartholomé, K. Josić, M. Arnold, M.G. Rosenblum, M.G. Rosenblum, M.G. Rosenblum, N.B. Janson, N.B. Janson, N.B. Janson, N.F. Rulkov, P. Tass, P.Y. Ktonas, R. Quian Quiroga, R.C. Mottram, S. Boccaletti, T. Sauer, T. Yalçınkaya, U. Parlitz, V.S. Anishchenko, W.J. Freeman   +37 more
core   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Compatibility Implementation Plan for Xi’an Metro Line 2 Phase Ⅰ and Phase Ⅱ Project Signaling Systems

Chengshi guidao jiaotong yanjiu
[Objective] The signaling system for Xi’an Metro Line 2 Phase Ⅰ project (hereinafter referred to as Line 2) utilizes an imported system, while Phase Ⅱ adopts a domestically developed system.
SUN Hui, REN Yaping, LIANG Bo
doaj   +1 more source

The Impact of a Digital Speaker on a Teacher's Interaction with a Child with Limited Functional Speech

South African Journal of Communication Disorders, 1999
This paper describes the impact of the implementation of a digital speaker and teacher training on the quality of a teacher's interaction with an AAC user. The data was obtained by recording and analysing classroom story time interactions.
Elsa Popich, Erna Alant
doaj   +1 more source

PENERAPAN AGRARISCHE WET (UNDANG-UNDANG AGRAIA) 1870: PERIODE AWAL SWASTANISASI PERKEBUNAN DI PULAU JAWA

Historia: Jurnal Pendidikan Sejarah FKIP UM Metro, 2020
The development of plantations in Indonesia is divided into two phases. The first phase is called the state plantation phase (1830-1870). Meanwhile, the second phase is the private plantation phase, the phase after the implementation of the Wet ...
M Masyrullahushomad, S Sudrajat
doaj   +1 more source

Monolithic simulation of convection-coupled phase-change - verification and reproducibility

, 2018
Phase interfaces in melting and solidification processes are strongly affected by the presence of convection in the liquid. One way of modeling their transient evolution is to couple an incompressible flow model to an energy balance in enthalpy ...
C Boettiger, DW Kelly, F Brezzi, GK Batchelor, HW Hsu, I Danaila, J Donea, J Kowalski, MS Dinniman, S Wang, UKNG Ghia, V Alexiades, VR Voller, VR Voller, W Bangerth, Y Belhamadia, Y Dutil   +16 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source