Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Surveillance of antimicrobial resistance in the United Arab Emirates: the early implementation phase. [PDF]
Front Public Health, 2023 Thomsen J +3 more
europepmc +1 more source
Teletrial implementation in early phase clinical trials: two national workshops
TrialsTeletrials aim to improve equity of access to clinical trials and increase clinical trial activity, especially for people with cancer in regional and rural communities.
Jessica Freeman +7 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Implementing a Hybrid Graduate Program: Lessons Learned One Year Later [PDF]
Journal of Systemics, Cybernetics and Informatics, 2016 Development of any graduate program is an extensive and timely process. Once the development phase is complete the program continues into the implementation phase.
Ronda Sturgill +2 more
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Evidence-Based Quality Improvement (EBQI) in the pre-implementation phase: key steps and activities. [PDF]
Front Health Serv, 2023 Swindle T +9 more
europepmc +1 more source
Implementasi Layanan Konsultasi Bimbingan dan Konseling di SMK Negeri se-Kota Semarang
Indonesian Journal of Guidance and Counseling: Theory and Application, 2017 This research was conducted based on phenomena that occur on guidance counseling teachers in vocational high school of Semarang. Implementation of consulting services guidance and counselling at the school in the execution not as appropriate, where ...
Aris Munandar, Heru Mugiarso
doaj
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source