Results 81 to 90 of about 591,472 (262)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Implementasi Layanan Konsultasi Bimbingan dan Konseling di SMK Negeri se-Kota Semarang

open access: yesIndonesian Journal of Guidance and Counseling: Theory and Application, 2017
This research was conducted based on phenomena that occur on guidance counseling teachers in vocational high school of Semarang. Implementation of consulting services guidance and counselling at the school in the execution  not as appropriate, where ...
Aris Munandar, Heru Mugiarso
doaj  

Protocol for iSISTAQUIT: Implementation phase of the supporting indigenous smokers to assist quitting project. [PDF]

open access: yesPLoS One, 2022
Gould Judean GS   +11 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

'A priori' external contextual factors and relationships with process indicators: a mixed methods study of the pre-implementation phase of 'Communities in Charge of Alcohol'. [PDF]

open access: yesBMC Public Health, 2022
Burns EJ   +9 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Design & Implementation of High Switching & Low Phase Noise Frequency Synthesizer

open access: yesAl-Khawarizmi Engineering Journal, 2006
This research describes the design & implementation of frequency synthesizer using single loop Phase lock loop with the following specifications: Frequency range (1.5 – 2.75) GHz,Step size (1 MHz), Switching time 36.4 µs, & phase noise @10 kHz = -92dBc &
Ali M. N. Hassan
doaj  

Phase III: Implementation and Operation of the repository [PDF]

open access: yes, 1998
The metadata catalog was brought online for public access May 14, 1998. Since then dozens of users have registered and began to access the system. The system was demonstrated at the AAPG annual meeting in Salt Lake City and the EAGE (European Association of Geoscientists and Engineers) annual meeting in Leipzig, Germany.
openaire   +4 more sources

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