Results 131 to 140 of about 2,679,990 (305)

Comparative effectiveness of implementation strategies for Accelerating Cervical Cancer Elimination through the integration of Screen-and-treat Services (ACCESS study): protocol for a cluster randomized hybrid type III trial in Nigeria

Implementation Science
Background Despite the increased risk of cervical cancer (CC) among women living with HIV (WLHIV), CC screening and treatment (CCST) rates remain low in Africa.
Babayemi O. Olakunde, Ijeoma U. Itanyi, John O. Olawepo, Lin Liu, Chinenye Bembir, Ngozi Idemili-Aronu, Nwamaka N. Lasebikan, Tonia C. Onyeka, Cyril C. Dim, Chibuike O. Chigbu, Echezona E. Ezeanolue, Gregory A. Aarons   +11 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Adapting the 2022 WHO verbal autopsy tool for use in Lagos State, Nigeria: insights from the LVASA-SRS project

BMC Research Notes
Objective Accurate and routine cause-of-death data are essential for health planning, yet many low- and middle-income countries lack comprehensive systems for such data, resulting in undocumented maternal and perinatal deaths.
Adeyemi Okunowo, Uchenna Gwacham-Anisiobi, Ndubuisi Ezumezu, Hameed Adelabu, Adedoyin Ogunyemi, Teniola Lawanson, Brenda Isikekpei, Bosede B. Afolabi, Aduragbemi Banke-Thomas   +8 more
doaj   +1 more source

Patient engagement, shared decision-making and equity, diversity and inclusion considerations in research ethics board application forms and templates in Canada: a mixed methods study

BMJ Open
Objectives Equity, diversity and inclusion (EDI), patient engagement and shared decision-making are important considerations throughout clinical trials, including the research ethics review stage. Meaningfully integrating these considerations can enhance
Dawn P Richards, Justin Presseau, Jamie C Brehaut, Kelly Carroll, Cole Etherington, Susan Marlin, Tamara L Morgan, Meena Mosa, Natasha Hudek, Kim Meeking   +9 more
doaj   +1 more source

Implementing DOIs for Research Data

D-Lib Magazine, 2012
Research is increasingly collaborative and global in nature, and efforts to manage the vast amounts of research data generated daily require global solutions. The Digital Object Identifier (DOI) system provides a means of persistent identification of research data collections and datasets that is global, standardised and widely used.
openaire   +3 more sources

Policy Dissemination Research

, 2012
This chapter outlines key issues of evidence-based theories and frameworks for policy dissemination research, discusses policy intervention design, and specifies potential challenges that may be faced in policy dissemination research.
Elizabeth A. Dodson, Ross C. Brownson, Dodson, Elizabeth A, Weiss, Stephen M, Brownson, Ross C, Stephen M. Weiss   +5 more
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Cost-Effectiveness of Interventions Related to the Treatment of Women With Polycystic Ovary Syndrome: A Scoping Review

International Journal of Women's Health
Emily Joy Callander,1,2 Yanan Hu,1 Alayna Carrandi,2 Chau Thien Tay,2 Aya Mousa,2 Helena Teede2 1School of Public Health, University of Technology Sydney, Sydney, NSW, Australia; 2Monash Centre for Health Research and Implementation, Monash University ...
Callander EJ, Hu Y, Carrandi A, Tay CT, Mousa A, Teede H   +5 more
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source