Results 111 to 120 of about 4,069,434 (300)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Quantum Computing, Metrology, and Imaging
, 2005 Information science is entering into a new era in which certain subtleties of quantum mechanics enables large enhancements in computational efficiency and communication security.
Dowling, Jonathan P. +2 more
core +2 more sources
Future Healthcare JournalDelivering meaningful change in healthcare is less about new discoveries and more about ensuring adoption at scale of what is already known to work.
Simon Barry, Chris Davies
doaj +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Implementing Generalized Empirical Method in Neuroscience by Functionally Ordering Tasks [PDF]
, 2016 This article outlines a method of collaboration that will manifest a high probability of cumulative and progressive results in science. The method will accomplish this through a division of labour grounded in the order of occurrence of
Henman, Robert
core
Perceived Risk for Severe COVID-19 and Oral Antiviral Use Among Antiviral-Eligible US Adults
Infectious Diseases and TherapyIntroduction Oral antiviral medications are important tools for preventing severe COVID-19 outcomes. However, their uptake remains low for reasons that are not entirely understood.
Kate Penrose +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Training Family Science Faculty in CORE Communication [PDF]
, 2017 As a whole and regardless of major, university graduates with interpersonal competence (also defined as soft skills) are viewed as more employable (Finch, Hamilton, Baldwin, & Zehner, 2013; Robles, 2012), yet interpersonal competence is not often ...
Chen, Jou-Chen +2 more
core +1 more source
npj Climate ActionDespite being an economists’ favorite, carbon pricing suffers from limited public support, undermining the feasibility of target-consistent prices. Revenue rebating is frequently considered as a remedy.
Maximilian Kellner +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source