Results 101 to 110 of about 1,033,408 (309)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Implementation science made too simple: a teaching tool

Implementation Science Communications, 2020
Background The field of implementation science is growing and becoming more complex. When teaching new learners, providing a clear definition of implementation science and a description of “its place” among related fields can be difficult.
Geoffrey M. Curran
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Investigating the implementation of infection prevention and control practices in neonatal care across country income levels: a systematic review

Antimicrobial Resistance and Infection Control
Background Despite the proven effectiveness of infection prevention and control (IPC) practices in reducing healthcare-associated infections and related costs, their implementation poses a challenge in neonatal care settings across high-income (HICs) and
Emanuela Nyantakyi, Julia Baenziger, Laura Caci, Kathrin Blum, Aline Wolfensberger, Angela Dramowski, Bianca Albers, Marta Castro, Marie-Therese Schultes, Lauren Clack   +9 more
doaj   +1 more source

The ‘goodness-of-fit’ of fit models: creating a multidimensional survey for person-organisation and person-group fit in health care

BMC Medical Research Methodology, 2020
Background Person-environment fit, which examines the individual’s perceptions of if, and in what way, he or she is compatible with aspects of the work context, offers a promising conceptual model for understanding employees and their interactions in ...
J. Herkes, L. A. Ellis, K. Churruca, J. Braithwaite   +3 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

What is public trust in national electronic health record systems? A scoping review of qualitative research studies from 1995 to 2021

Digital Health
Objective Public trust in national electronic health record systems is essential for the successful implementation within a healthcare system. Research investigating public trust in electronic health records is limited, leading to a lack of conceptual ...
Kimon Papadopoulos, Viktor von Wyl, Felix Gille   +2 more
doaj   +1 more source

A randomized controlled trial in schools aimed at exploring mechanisms of change of a multifaceted implementation strategy for promoting mental health at the workplace

, 2022
Background This study will explore implementation mechanisms through which a single implementation strategy and a multifaceted implementation strategy operate to affect the implementation outcome, which is fidelity to the Guideline For The Prevention of ...
Kwak, Lydia, Lengnick-Hall, Rebecca,, Stigmar, Kjerstin, Bergström, Gunnar,, Powell, Byron J.,, Lengnick-Hall, Rebecca, Wåhlin, Charlotte, Björklund, Christina, Powell, Byron J, Kwak, Lydia,, Toropova, Anna, Elinder, Liselotte Schäfer,, Wåhlin, Charlotte,, Jensen, Irene,, Schäfer Elinder, Liselotte,, Jensen, Irene, Toropova, Anna,, Powell, Byron J., Elinder, Liselotte Schäfer, Stigmar, Kjerstin,, Bergström, Gunnar, Schäfer Elinder, Liselotte, Björklund, Christina,   +22 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Healthcare workers’ perspectives on patient bypassing of Primary Health Care facilities in Mpumalanga province, South Africa

African Journal of Primary Health Care & Family Medicine
Background: South Africa’s Referral Policy and Implementation Guidelines aim to ensure continuity of care, manage patient flow, and improve health system efficiency. However, in Mpumalanga province, a growing number of patients bypass Primary Health Care
Thobelani N. Majola, Ntombifuthi Blose, Mashudu Mthethwa, Zinhle Mtwane, Algernon M. Africa, Matome S. Mokganya, James M. Burnett, Noluthando Ndlovu, Ashnie Padarath   +8 more
doaj   +1 more source