Results 81 to 90 of about 1,033,408 (309)

The use of the PARIHS framework in implementation research and practice : A citation analysis of the literature

, 2020
BACKGROUND: The Promoting Action on Research Implementation in Health Services (PARIHS) framework was developed two decades ago and conceptualizes successful implementation (SI) as a function (f) of the evidence (E) nature and type, context (C) quality ...
Gustafsson, K., Kitson, Alison,, Ehrenberg, Anna,, Bergström, Anna, Gustafsson, Kazuko, Graham, Ian D., Rycroft-Malone, J., Ehrenberg, Anna, Rycroft-Malone, Jo, Eldh, A.C., Graham, Ian D.,, Kitson, A., Eldh, Ann Catrine, Harvey, Gillian, Graham, I.D., Graham, Ian D, Gustafsson, Kazuko,, Kitson, Alison, Wallin, Lars,, Harvey, G., Hunter, Sarah, Hunter, Sarah,, Harvey, Gillian,, Graham, Ian, Bergstrom, Anna,, Eldh, Ann Catrine,, Ehrenberg, A., Wallin, L., Rycroft-Malone, Jo,, Hunter, S., Bergström, A., Wallin, Lars   +31 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

iSPARC 2024 Annual Report to the Massachusetts Department of Mental Health

In fiscal year 2024, iSPARC continued to leverage DMH’s investment to rapidly translate research findings into their implementation within best practices for individuals with lived experience, their families, and the providers who serve them across the ...
Implementation Science and Practice Advances Research Center
core   +1 more source

Alignment in implementation of evidence-based interventions : a scoping review

, 2021
Background: Alignment (i.e., the process of creating fit between elements of the inner and outer context of an organization or system) in conjunction with implementation of an evidence-based intervention (EBI) has been identified as important for ...
Leif Eriksson, Eriksson, Leif, Khachatryan, Ermine, Lundmark, Robert,, Hasson, H,, Anne Richter, Richter, Anne,, Lundmark, R, Eriksson, L, Eriksson, Leif,, Amanda Åkesson, Khachatryan, E, Richter, Anne, Åkesson, Amanda, Ermine Khachatryan, Robert Lundmark, Åkesson, Amanda,, Hasson, Henna, Khachatryan, Ermine,, Akesson, A, Richter, A,, Henna Hasson, Hasson, Henna,, Lundmark, Robert   +23 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Progress with the Learning Health System 2.0: a rapid review of Learning Health Systems’ responses to pandemics and climate change

BMC Medicine
Background Pandemics and climate change each challenge health systems through increasing numbers and new types of patients. To adapt to these challenges, leading health systems have embraced a Learning Health System (LHS) approach, aiming to increase the
Carolynn L. Smith, Georgia Fisher, Putu Novi Arfirsta Dharmayani, Shalini Wijekulasuriya, Louise A. Ellis, Samantha Spanos, Genevieve Dammery, Yvonne Zurynski, Jeffrey Braithwaite   +8 more
doaj   +1 more source

The journey to a learning health system in primary care: a qualitative case study utilising an embedded research approach

BMC Primary Care, 2023
Background Healthcare systems may be resilient and adaptive, but they are not fit for purpose in their current state. Increasing threats to health system sustainability have underscored the need to move towards a learning health system in which research ...
Genevieve Dammery, Louise A. Ellis, Kate Churruca, Janani Mahadeva, Francisco Lopez, Ann Carrigan, Nicole Halim, Simon Willcock, Jeffrey Braithwaite   +8 more
doaj   +1 more source

How can a behavioral economics lens contribute to implementation science?

Background Implementation science in health is an interdisciplinary field with an emphasis on supporting behavior change required when clinicians and other actors implement evidence-based practices within organizational constraints.
Beidas, Rinad S, Rinad S. Beidas, Nilsen, Per, Nilsen, Per,, Powell, Byron J.,, Powell, Byron J, Hodson, Nathan, Nathan Hodson, Beidas, Rinad S., Hodson, Nathan,, Beidas, Rinad S.,, Byron J. Powell, Powell, Byron J., Per Nilsen   +13 more
core   +1 more source

A Guide to SDG Interactions: from Science to Implementation

, 2017
The report examines the interactions between the various goals and targets, determining to what extent they reinforce or conflict with each other. It provides a blueprint to help countries implement and achieve the Sustainable Development Goals (SDGs).
International Council for Science
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source