Results 81 to 90 of about 31,672,605 (212)

What is public trust in national electronic health record systems? A scoping review of qualitative research studies from 1995 to 2021

Digital Health
Objective Public trust in national electronic health record systems is essential for the successful implementation within a healthcare system. Research investigating public trust in electronic health records is limited, leading to a lack of conceptual ...
Kimon Papadopoulos, Viktor von Wyl, Felix Gille   +2 more
doaj   +1 more source

A scoping review of implementation science theories, models, and frameworks — an appraisal of purpose, characteristics, usability, applicability, and testability

, 2023
Background A proliferation of theories, models, and frameworks (TMFs) have been developed in the implementation science field to facilitate the implementation process. The basic features of these TMFs have been identified by several reviews.
Wong, Eliza Lai-Yi,, Nilsen, Per, Yingxuan Wang, Wang, Yingxuan,, Nilsen, Per,, Chung, Vincent Chi-ho,, Chung, Vincent Chi-ho, Yeoh, Eng-Kiong,, Tian, Yue, Eliza Lai-Yi Wong, Wang, Yingxuan, Yeoh, Eng-Kiong, Tian, Yue,, Vincent Chi-ho Chung, Per Nilsen, Yue Tian, Eng-Kiong Yeoh, Wong, Eliza Lai-Yi   +17 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Implementation science made too simple: a teaching tool

Implementation Science Communications, 2020
Background The field of implementation science is growing and becoming more complex. When teaching new learners, providing a clear definition of implementation science and a description of “its place” among related fields can be difficult.
Geoffrey M. Curran
doaj   +1 more source

Rethinking barriers and facilitators in implementation science: conceptual, methodological, and practical challenges, and ways forward

Implementation science has long relied on the concepts of barriers and facilitators (B&F) to explain why evidence-based practices succeed or fail. Determinant frameworks such as the Consolidated Framework for Implementation Research and Theoretical ...
Nilsen, Per, Nilsen, Per,
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

SARS-CoV-2 testing behavior in symptomatic adults in a U.S. national cohort, 2020–2023: influence of exposure risk, susceptibility and healthcare access

BMC Public Health
Background COVID-19 continues to circulate and cause illness, hospitalizations and death in the U.S, underscoring the importance of understanding SARS-CoV-2 testing behavior among symptomatic adults.
Jenna Sanborn, Saba Qasmieh, Kate Penrose, Angela Parcesepe, Yanhan Shen, Rachael Piltch-Loeb, Josefina Nuñez, Denis Nash, McKaylee Robertson   +8 more
doaj   +1 more source

Healthcare workers’ perspectives on patient bypassing of Primary Health Care facilities in Mpumalanga province, South Africa

African Journal of Primary Health Care & Family Medicine
Background: South Africa’s Referral Policy and Implementation Guidelines aim to ensure continuity of care, manage patient flow, and improve health system efficiency. However, in Mpumalanga province, a growing number of patients bypass Primary Health Care
Thobelani N. Majola, Ntombifuthi Blose, Mashudu Mthethwa, Zinhle Mtwane, Algernon M. Africa, Matome S. Mokganya, James M. Burnett, Noluthando Ndlovu, Ashnie Padarath   +8 more
doaj   +1 more source

Making sense of implementation theories, models and frameworks [PDF]

, 2015
Background: Implementation science has progressed towards increased use of theoretical approaches to provide better understanding and explanation of how and why implementation succeeds or fails.
Nilsen, Per, Nilsen, Per,, Per Nilsen
core   +2 more sources