Results 91 to 100 of about 1,033,408 (309)

A beginner's guide to implementation scienceCentral Message

JTCVS Techniques
Dominique de Waard, MD, MSc, Ryan Gainer, MSc, Meaghan Sim, PhD, RD, Claudia Cote, MD, MSc, Philippe Tremblay, MD, MSc, Paul Bonnar, MD, Gregory Hirsch, MD   +6 more
doaj   +4 more sources

Revisiting the scope and expectations of Implementation Science and Implementation Science Communications

Implementation Science
AbstractThis editorial updates the scope and submission expectations of Implementation Science and Implementation Science Communications. We refine our protocol publishing policies and set out new expectations for reporting studies describing determinants and their relationship with implementation outcomes.
Wilson, Paul, Aarons, Gregory A, Sales, Anne, Xu, Dong Roman, Wensing, Michel, Hutchinson, Alison, Beidas, Rinad S, Geng, Elvin   +7 more
openaire   +4 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Developing implementation research capacity: longitudinal evaluation of the King’s College London Implementation Science Masterclass, 2014–2019

Implementation Science Communications, 2020
Background Despite an increasing number of training opportunities in implementation science becoming available, the demand for training amongst researchers and practitioners is unmet.
Rachel Davis, Brian Mittman, Madelene Boyton, Aoife Keohane, Lucy Goulding, Jane Sandall, Graham Thornicroft, Nick Sevdalis   +7 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Learning health systems on the front lines to strengthen care against future pandemics and climate change: a rapid review

BMC Health Services Research
Background An essential component of future-proofing health systems against future pandemics and climate change is strengthening the front lines of care: principally, emergency departments and primary care settings.
Samantha Spanos, Genevieve Dammery, Lisa Pagano, Louise A. Ellis, Georgia Fisher, Carolynn L. Smith, Darran Foo, Jeffrey Braithwaite   +7 more
doaj   +1 more source

Barriers to Childhood Immunisation in Selected Zero-Dose Communities in Gauteng Province: A Qualitative Study

Vaccines
Background/objective: The Immunisation Agenda 2030, led by the World Health Organization, aims to ensure that people of all ages benefit from vaccination. South Africa remains committed to these goals, strengthening childhood immunisation largely through
Thobelani Nompilo Majola, Ntombifuthi Blose, Emma Shuvai Chikovore, Zinhle Mtwane, Algernon Africa, James Michael Burnett, Maanda Mudau, Noluthando Ndlovu, Bontle Motloung, Janine Simon-Meyer, Ashnie Padarath   +10 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Making sense of implementation theories, models and frameworks

, 2015
Background: Implementation science has progressed towards increased use of theoretical approaches to provide better understanding and explanation of how and why implementation succeeds or fails.
Nilsen, Per, Nilsen, Per,, Per Nilsen
core   +1 more source

Education, Implementation, and Teams 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations

, 2020
: For this 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations, the Education, Implementation, and Teams Task Force applied the population, intervention, comparator ...
Breckwoldt, Jan, Finn, Judith C, Pellegrino, Jeffrey L., Iwami, Taku, Lauridsen, Kasper G, Hsieh, Ming-Ju, Bigham, Blair L., Bigham, Blair L, Gilfoyle, Elaine, Cheng, Adam, Monsieurs, Koenraad G., Monsieurs, Koenraad G, Yeung, Joyce, Lauridsen, Kasper G., Lockey, Andrew S., Finn, Judith C., Okamoto, Deems, Monsieurs, Koen, Huei-Ming Ma, Matthew, Greif, Robert, Duff, Jonathan P., Pellegrino, Jeffrey L, Bhanji, Farhan, Ma, Matthew Huei-Ming, Duff, Jonathan P, Lockey, Andrew S, Bray, Janet   +26 more
core   +1 more source