Results 111 to 120 of about 1,033,408 (309)

Primary science in Malaysia: the implementation of a new curriculum [PDF]

This thesis investigates the implementation of the science curriculum in Malaysian primary schools. The study is concerned primarily with teachers' pedagogical content knowledge as a crucial determinant of teaching performance in implementing the new ...
Yunus, Hashimah Mohd.
core  

Efficacious, effective, and embedded interventions: Implementation research in infectious disease control [PDF]

, 2008
Background: Research in infectious disease control is heavily skewed towards high end technology; development of new drugs, vaccines and clinical interventions.
Skelly, William C, Allotey, Pascale, Skelly, WC, Reidpath Daniel D, William C Skelly, Pascale Allotey, Skelly William C, Pagnoni Franco, Pagnoni, F, Allotey, P, Ghalib, Hashim, Daniel D Reidpath, Franco Pagnoni, Reidpath, Daniel, Ghalib Hashim, Hashim Ghalib, Reidpath, DD, Allotey Pascale, Pagnoni, Franco, Ghalib, H   +19 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The goldilocks effect: the rhythms and pace of hospital life

BMC Health Services Research, 2018
Background While we have made gains in understanding cultures in hospitals and their effects on outcomes of care, little work has investigated how the pace of work in hospitals is associated with staff satisfaction and patient outcomes.
Jeffrey Braithwaite, Louise A. Ellis, Kate Churruca, Janet C. Long   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Data-driven approach to implementation mapping for the selection of implementation strategies: a case example for risk-aligned bladder cancer surveillance

, 2022
BACKGROUND: Implementation Mapping is an organized method to select implementation strategies. However, there are 73 Expert Recommendations for Implementing Change (ERIC) strategies.
Ould Ismail, A. Aziz, Walker, DeRon R., Zubkoff, Lisa, Ismail, A. Aziz Ould, Schroeck, Florian R., Sanchez, Steven L., Haggstrom, David A.   +6 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Health system performance on greenhouse gas emissions, climate change and development status in 38 OECD countries

Scientific Reports
Health systems must solve two climate-related problems simultaneously: mitigate their greenhouse gas emissions and adapt to additional patient loads associated with climate-induced demands for care from weather sequalae and vector-borne diseases.
Jeffrey Braithwaite, Yvonne Tran, Georgia Fisher, Louise A Ellis, Carolynn L Smith, Yvonne Zurynski   +5 more
doaj   +1 more source

The DECIDE Science Gateway [PDF]

, 2013
The motivation of this work fits with the general vision to enable e-health for European citizens, irrespective of their social and financial status and their place of residence.
Ingrà Elisa, Fargetta Marco, Nuclear Physics, Monforte Salvo, Barbera Roberto, Rotondo Riccardo, La Rocca Giuseppe, Scardaci Diego, Ardizzone Valeria, Porro Ivan, Schenone Andrea, Calanducci Antonio, Ricceri Rita   +12 more
core   +1 more source

Study protocol for a type III hybrid effectiveness-implementation trial to evaluate scaling interoperable clinical decision support for patient-centered chronic pain management in primary care

, 2022
BACKGROUND: The US continues to face public health crises related to both chronic pain and opioid overdoses. Thirty percent of Americans suffer from chronic noncancer pain at an estimated yearly cost of over $600 billion.
Modave, François, Paz, Laura Gonzalez, Hurley, Robert W., Nguyen, Khoa, Bian, Jiang, McDonnell, Cara, Gutierrez, Maria, Siler, Kendra, Willis, David, Martinez‑Wittinghan, Francisco, Salloum, Ramzi G., Rhodes, Bryn, Militello, Laura G., Harle, Christopher A., Marcial, Laura, Jones, Ross E., Masri, Ghania, Martinez-Wittinghan, Francisco, Diiulio, Julie, Bilello, Lori, Gurka, Matthew J., Gonzalez Paz, Laura   +21 more
core   +1 more source