Results 111 to 120 of about 31,672,605 (212)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Equity-focused analysis of tailoring strategies for overcoming risk factors in ethnic minorities (EQUATOR): a protocol for a scoping review with a realist analysis

BMJ Open
Introduction Chronic diseases driven by modifiable risk factors (MRFs), such as poor diet, physical inactivity, tobacco use and harmful alcohol consumption, disproportionately affect ethnic minority groups worldwide and within multi‑ethnic societies such
Nick Sevdalis, G.J. Melendez-Torres, Jumana Hashim, Conor Luck, Niharika Rustagi   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Implementation Science

, 2017
Purpose This paper is one of seven in this volume elaborating upon different approaches to quality improvement in education. This paper aims to delineate a methodology called Implementation Science, focusing on methods to enhance the reach, adoption ...
Elaine Berrena, Paul G. LeMahieu, Lee E. Nordstrum   +2 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Perceived Risk for Severe COVID-19 and Oral Antiviral Use Among Antiviral-Eligible US Adults

Infectious Diseases and Therapy
Introduction Oral antiviral medications are important tools for preventing severe COVID-19 outcomes. However, their uptake remains low for reasons that are not entirely understood.
Kate Penrose, Avantika Srivastava, Yanhan Shen, McKaylee M. Robertson, Sarah G. Kulkarni, Kristen E. Allen, Thomas M. Porter, Laura Puzniak, John M. McLaughlin, Denis Nash   +9 more
doaj   +1 more source

Creating system-wide change in medicine: The role of implementation science in achieving scale and adoption

Future Healthcare Journal
Delivering meaningful change in healthcare is less about new discoveries and more about ensuring adoption at scale of what is already known to work.
Simon Barry, Chris Davies
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Boosting public support for climate policy through information provision: insights from German survey experiments

npj Climate Action
Despite being an economists’ favorite, carbon pricing suffers from limited public support, undermining the feasibility of target-consistent prices. Revenue rebating is frequently considered as a remedy.
Maximilian Kellner, Karolina Rütten, Mattis Geiger, Mirjam A. Jenny, Lena Lehrer, Hellen Temme, Cornelia Betsch   +6 more
doaj   +1 more source

CARE-Emory Implementation Science Partnership

The CARE–Emory Implementation Science Partnership is a collaborative initiative between CARE USA and Emory University aimed at advancing the use of implementation science within development and humanitarian ...
Jedidiah Snyder, Matthew Freeman
core   +1 more source