Results 111 to 120 of about 4,099,697 (298)

Implementation science at the crossroads [PDF]

BMJ Quality & Safety, 2017
Martin Marshall and colleagues1 take themselves to task for the suboptimal design of a complex (multicomponent) intervention to improve safety of services for people in care homes. The authors make much of the complexity of the intervention—service interventions are ‘not like a pill’.
openaire   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Perceived Risk for Severe COVID-19 and Oral Antiviral Use Among Antiviral-Eligible US Adults

Infectious Diseases and Therapy
Introduction Oral antiviral medications are important tools for preventing severe COVID-19 outcomes. However, their uptake remains low for reasons that are not entirely understood.
Kate Penrose, Avantika Srivastava, Yanhan Shen, McKaylee M. Robertson, Sarah G. Kulkarni, Kristen E. Allen, Thomas M. Porter, Laura Puzniak, John M. McLaughlin, Denis Nash   +9 more
doaj   +1 more source

Creating system-wide change in medicine: The role of implementation science in achieving scale and adoption

Future Healthcare Journal
Delivering meaningful change in healthcare is less about new discoveries and more about ensuring adoption at scale of what is already known to work.
Simon Barry, Chris Davies
doaj   +1 more source

Applying Science Models for Search [PDF]

, 2011
The paper proposes three different kinds of science models as value-added services that are integrated in the retrieval process to enhance retrieval quality.
Mayr, Philipp, Mutschke, Peter, Petras, Vivien, Schaer, Philipp, Sure, York   +4 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Boosting public support for climate policy through information provision: insights from German survey experiments

npj Climate Action
Despite being an economists’ favorite, carbon pricing suffers from limited public support, undermining the feasibility of target-consistent prices. Revenue rebating is frequently considered as a remedy.
Maximilian Kellner, Karolina Rütten, Mattis Geiger, Mirjam A. Jenny, Lena Lehrer, Hellen Temme, Cornelia Betsch   +6 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Organizational readiness for implementing infection control in European hospitals: insights from Coincidence Analysis

Implementation Science Communications
Background Healthcare-associated infections (HAIs) are a threat to public health, however, infection prevention and control (IPC) interventions have been shown to prevent a substantial portion of HAIs.
Laura Caci, Kathrin Blum, Clara Johnson, Bianca Albers, Lauren Clack, The REVERSE study group   +5 more
doaj   +1 more source