Results 61 to 70 of about 4,069,434 (300)

Organisational change in hospitals: a qualitative case-study of staff perspectives

BMC Health Services Research, 2019
Background Organisational change in health systems is common. Success is often tied to the actors involved, including their awareness of the change, personal engagement and ownership of it.
Chiara Pomare, Kate Churruca, Janet C. Long, Louise A. Ellis, Jeffrey Braithwaite   +4 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Instructional Materials and Implementation of Next Generation Science Standards: Demand, Supply, and Strategic Opportunities [PDF]

, 2017
Next Generation Science Standards (NGSS) are in demand, but the supply of high quality K-12 instructional materials in science is lacking. This disconnect comes at a critical time in the implementation of new science standards, which are now influencing ...
Christine Chopyak, Rodger Bybee
core  

AMP: A Science-driven Web-based Application for the TeraGrid

, 2009
The Asteroseismic Modeling Portal (AMP) provides a web-based interface for astronomers to run and view simulations that derive the properties of Sun-like stars from observations of their pulsation frequencies.
Metcalfe, Travis, Shorrock, Ian, Woitaszek, Matthew   +2 more
core   +1 more source

Keck Interferometer Nuller Data Reduction and On-Sky Performance [PDF]

, 2009
We describe the Keck Interferometer nuller theory of operation, data reduction, and on-sky performance, particularly as it applies to the nuller exozodiacal dust key science program that was carried out between 2008 February and 2009 January.
Akeson, R. L., Appleby, E. C., Berkey, B. C., Booth, A. J., Colavita, M. M., Cooper, A., Crawford, S. L., Creech-Eakman, M. J., Dahl, W., Felizardo, C., Garcia-Gathright, J. I., Gathright, J. T., Herstein, J. S., Hovland, E. E., Hrynevych, M. A., Koresko, C. D., Ligon, E. R., Medeiros, D. W., Mennesson, B. P., Millan-Gabet, R., Moore, J. D., Morrison, D., Paine, C. G., Palmer, D. L., Panteleeva, T., Ragland, S. D., Serabyn, E., Smith, B., Smythe, R. F., Summers, K. R., Swain, M. R., Tsubota, K., Tyau, C., Vasisht, G., Wetherell, E., Wizinowich, P. L., Woillez, J. M.   +36 more
core   +1 more source

Implementation science: why should we care?

Journal of the Medical Library Association
There is a 17-year gap between the publication of research which proves an intervention is  efficacious and effective and the implementation of that same intervention into practice [1].
Frances Chu
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

HotGrid: Graduated Access to Grid-based Science Gateways [PDF]

, 2004
We describe the idea of a Science Gateway, an application-specific task wrapped as a web service, and some examples of these that are being implemented on the US TeraGrid cyberinfrastructure.
Bunn, Julian, Steenberg, Conrad, Williams, Roy   +2 more
core  

Adapting the 2022 WHO verbal autopsy tool for use in Lagos State, Nigeria: insights from the LVASA-SRS project

BMC Research Notes
Objective Accurate and routine cause-of-death data are essential for health planning, yet many low- and middle-income countries lack comprehensive systems for such data, resulting in undocumented maternal and perinatal deaths.
Adeyemi Okunowo, Uchenna Gwacham-Anisiobi, Ndubuisi Ezumezu, Hameed Adelabu, Adedoyin Ogunyemi, Teniola Lawanson, Brenda Isikekpei, Bosede B. Afolabi, Aduragbemi Banke-Thomas   +8 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source