Results 41 to 50 of about 665,454 (302)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The Dynamic Routing Protocol Implementation Strategy of the Cooperative Control Awareness Combat Network

Applied Sciences, 2018
In view of the problem of dynamically setting up a fire aiming data chain between the sensors and the shooters in the same battle echelon in the awareness combat network (ACNET) of the future unmanned collaborative combat system, based on the wireless ...
Cheng-Hai Wu, Kai-Yu Qin, Ping Li, Guo-Hui Wu   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The Implementation of Religious Moderation in the Quran and Hadith Learning At Islamic Senior High Schools in Aceh

DAYAH
This study aims to determine the implementation of religious moderation in Qur'an and hadith learning at State Islamic Senior High Schools in Aceh Province.
M. Chalis M.Chalis, Suhaimi Suhaimi, Sulaiman Sulaiman   +2 more
doaj   +1 more source

From novice to expert: methods for transferring implementation facilitation skills to improve healthcare delivery

Implementation Science Communications, 2021
Background There is substantial evidence that facilitation can address the challenges of implementing evidence-based innovations. However, facilitators need a wide variety of complex skills; lack of these can have a negative effect on implementation ...
Mona J. Ritchie, Louise E. Parker, JoAnn E. Kirchner   +2 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Reflections on the development and construction of space-ground integration information network

Dianxin kexue, 2017
When maintaining and expanding national interests,our country’s information network has always been faced with the problem of “covering beyond its control,incompatible with information,slow in response to services and having security risks”.Building a ...
Wei WU, Peng QIN, Xu FENG, Haijiao LIU, Zhaoxiang HUANG   +4 more
doaj  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Generalised strategy for implementing the minimum fault reactance based fault location algorithm in real power distribution systems

Ingeniería e Investigación, 2011
The paper presented here is aimed at proposing a generalised strategy for easily implementing a fault locator in real power distribution systems. The strategy is based on the definition of a fault location method and its successive application along ...
E. Correa-Tapasco, J. Mora-Flórez, S. Pérez-Londoño   +2 more
doaj