Results 51 to 60 of about 8,531 (254)
Cahiers Balkaniques, 2014 This article re-evaluates the evolution of Cypriots’ socio-political situation in the “long term”, by comparing the periods of domination of the Lusignan, the Venetians and the Ottomans.
Mathieu Petithomme
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
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School Mathematics Teachers Are Super Heroes
Southeast Asian Mathematics Education Journal, 2011 Hollywood has produced many super heroes such as Superman, Batman and Wonder Woman. Recently it released a film titled 'Waiting for Superman' which shows a young boy imprisoned within a system and classroom that does not stimulate his learning while ...
Allan Leslie White
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
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Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
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Revista Vasca de Administración Pública, 2017 The transformation of the principle of market unity in Spain is rooted in a two-fold phenomenon. First, its deconstitutionalization has implied a greater prominence of infraconstitutional norms and an administrative and ordinary judicial supervisory ...
Joan Solanes Mullor
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
EL TRIBUNAL CONSTITUCIONAL, ¿"SEMPRE, NOMÉS... I INDISCUTIBLE"? LA FUNCIÓ CONSTITUCIONAL DELS ESTATUTS EN L'ÀMBIT DE LA DISTRIBUCIÓ DE COMPETÈNCIES SEGONS LA STC 31/2010 [PDF]
Revista d'Estudis Autonòmics i Federals, 2011 This article analyses the effects that Spain’s Constitutional Court’s Ruling(hereafter referred to as the CCR) has had upon the constitutional functionof the 2006 Statute of Autonomy of Catalonia (SAC) – and of the statutes ofautonomy in general ...
Carles Viver Pi-Sunyer
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