Results 71 to 80 of about 8,531 (254)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

The Role of the UN Secretary-General in Maintaining International Peace and Security: Focusing on António Guterres’ Performance [PDF]

Iranian Journal of International and Comparative Law
The Secretary-General of the United Nations, as one of the principal organs of the Organization,plays an important role in maintaining international peace and security.
Fatemeh Fouladi, Elham Aminzadeh, Fatemeh Eisakhan   +2 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Privacy and Hacking Powers: Is there an Implied Right to Privacy in the Use of Computer Surveillance Powers in Australia?

Salus Journal
On 3 September 2021, Australia’s Commonwealth Parliament passed the Surveillance Legislation Amendment (Identify and Disrupt) Act 2021 (Cth). In doing so, it added to an already expansive regime of warrants and authorisations, enabling law enforcement ...
Brendan Walker-Munro, Ruby Ioannou , David Mount   +2 more
doaj  

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

‘No Diplomatic Negotiations or Insistence before the Ottoman Porte to Have Any Favorable Result...’: The Caucasus in Russian-Turkish Relations, Late Nineteenth and Early Twentieth Centuries

Oriental Studies
Introduction. Being a key point on the Russian-Turkish agenda during the period in question, the Caucasus was influenced not only by the traditional logic of geopolitical rivalry between the two powers but also by somewhat tectonic shifts in the system ...
Karine R. Ambartsumyan, Mikayel A. Malkhasyan, Vahram R. Balayan   +2 more
doaj   +1 more source

Le modèle québécois : origines, définition, fondements et adaptation au nouveau contexte économique et social

Revue Interventions Économiques, 2002
From several papers on the Quebecois model and Quebec Inc ., the article shows that these terms take several meanings according to the authors. So, for some, they translate a corporatist, a real network or an economic nationalism; for others, they are ...
Pierre-Paul Proulx
doaj   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source