Results 51 to 60 of about 1,757,599 (384)

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

Can Innovation Help U.S. Manufacturing Firms Escape Import Competition from China?

open access: yesJournal of Finance, 2015
We study whether R&D-intensive firms are more resilient to trade shocks. We correct for the endogeneity of R&D using tax-induced changes to the cost of R&D.
J. Hombert, Adrien Matray
semanticscholar   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

open access: yesMolecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane   +16 more
wiley   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

The Importance of 'The Gap'

open access: yesSSRN Electronic Journal, 2016
35 University of Queensland Law Journal 47-56 (2016)One of the central dilemmas of law is what Larry Alexander has called "the gap:" general, determinate rules have significant benefits from the forward-looking perspective of a lawmaker, but generate outcomes that appear wrong from the perspective of individual actors.
Emily Sherwin, Cornell Law Library
openaire   +3 more sources

Fiction and importation [PDF]

open access: yesLinguistics and Philosophy, 2021
AbstractImportation in fictional discourse is the phenomenon by which audiences include information in the story over and above what is explicitly stated by the narrator. This paper argues that importation is distinct from generation, the phenomenon by which truth in fiction may outstrip what is made explicit, and draws a distinction between fictional ...
openaire   +3 more sources

Economic development of Sudan [PDF]

open access: yesAkademičnij Oglâd, 2018
The article presents the descriptive analysis of level of economic, political and social development of Sudan according to the global trends. An analysis of the country’s development trends and the dependence of the national market on the global ...
O. CHORNA, S. AL-NAAMANI, S. AL-MASKARI
doaj   +1 more source

Openness of the economy as a determinant of economic growth: The panel analysis of the Western Balkans region countries [PDF]

open access: yesEkonomski Pogledi, 2020
The openness of the economy and its intensive involvement in international trade and economic flows has an important role in stimulating economic growth and development of a national economy.
Bugarčić Filip Ž., Veselinović Petar
doaj   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

CONSIDERING THE PROSPECTS OF PARALLEL IMPORT

open access: yesВестник университета, 2019
The issue of parallel import is сomplex. The problem has geopolitical nature. The price of the existing ban is billions of dollars in overpayment for imported goods per year, because of it, the structure of domestic trade in Russia is extremely ...
V. Kardanov
doaj   +1 more source

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