Results 191 to 200 of about 451,111 (312)
Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling
Advanced Science, EarlyView.We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer +13 morewiley +1 more sourceAssessment of genetically modified cotton GHB614 × T304-40 × GHB119 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (application EFSA-GMO-NL-2014-122). [PDF]
EFSA J, 2018 EFSA Panel on Genetically Modified Organisms (EFSA GMO Panel), Naegeli H, Birch AN, Casacuberta J, De Schrijver A, Gralak MA, Guerche P, Jones H, Manachini B, Messéan A, Nielsen EE, Nogué F, Robaglia C, Rostoks N, Sweet J, Tebbe C, Visioli F, Wal JM, Ardizzone M, Fernandez-Dumont A, Gennaro A, Gómez Ruiz JÁ, Lanzoni A, Neri FM, Papadopoulou N, Paraskevopoulos K. +25 moreeuropepmc +1 more sourceβ‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma
Advanced Science, EarlyView.β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit +20 morewiley +1 more sourcePET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe
Advanced Science, EarlyView.This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao +14 morewiley +1 more sourceMitochondrial protein import [PDF]
, 1989 Ades, Ades, Adrian, Ainger, Allison, Alt, Aquila, Aquila, Arakawa, Arends, Argan, Argan, Baker, Banroques, Basile, Beckmann, Bedwell, Behra, Bellion, Beltzer, Beltzer, Berkhout, Bhasker, Bhat, Blobel, Borst, Bouillaud, Boutry, Brandriss, Braun, Burns, Böhni, Böhni, Cerletti, Chatton, Chen, Chen, Chen, Chen, Chen, Cheng, Chien, Chien, Chirico, Chu, Conboy, Conboy, Coruzzi, Craig, Dahl, Daum, Daum, De Haan, De Jong, De Lange, De Lange, Deshaies, Dickerson, Dieckmann, Dieckmann, Douglas, Duffaud, Dumont, Eilers, Eilers, Eilers, Ellis, Ellis, Emr, Epand, Evans, Farrell, Farrell, Faye, Firgaira, Fisher, Flügge, Foury, Fox, Freeman, Freitag, Fujiki, Fujiki, Gabellini, Gabellini, Gasser, Gasser, Gasser, Gay, Gearing, Geller, Gillespie, Gilmore, Gilmore, Grant, Grossmann, Guiard, Hackenbrock, Hallemayer, Hallermayer, Hallewell, Hampsey, Hansen, Harmey, Harmey, Harmey, Harmey, Harnisch, Hartl, Hartl, Hartl, Hartl, Hase, Hase, Hase, Hatalova, Hauska, Hawlitschek, Hay, Heinrich, Hemmingsen, Hennig, Hennig, Hennig, Henning, Hensgen, Ho, Ho, Horwich, Horwich, Horwich, Horwich, Horwich, Horwich, Hunter, Hurt, Hurt, Hurt, Hurt, Hurt, Hurt, Hurt, Hurt, Imanaka, Ito, Jaussi, Jaussi, Joh, Just, Kanazawa, Kaput, Kellems, Kellems, Kellens, Keng, Kirwin, Kleene, Koerner, Koerner, Koike, Kolansky, Kolarov, Korb, Kraus, Kraus, Kraus, Kraus, Krebs, Kruse, Kryzwicki, Kun, Labouesse, Lazarow, Lederer, Lennart-Nilsson, Lewin, Lewin, Lindquist, Lingelbach, Lomax, Lubben, Lustig, Lustig, Maarse, Maarse, Maccecchini, Maccecchini, Macino, Maher, Marres, Marzuki, Matsubara, Matsuura, McAda, McGraw, McIntyre, Meyer, Meyer, Meyer, Michel, Mihara, Mihara, Mihara, Mihara, Miura, Miura, Mori, Mori, Morita, Morohashi, Morohashi, Morohashi, Mueckler, Mueckler, Mueckler, Myers, Myers, Müller, Müller, Nagata, Nakagawa, Nargang, Natsoulis, Nelson, Nelson, Ness, Neupert, Neupert, Nguyen, Nguyen, Nguyen, Nguyen, Nicholson, Nicholson, Nicholson, Nicholson, Nishikimi, Nyunoya, Oda, Oda, Ohashi, Ohba, Ohba, Ohta, Ohta, Okamura, Okamura, Ono, Ono, Ono, Ono, Ou, Ou, Oudshoorn, Pain, Pain, Pape, Pape, Park, Patterson, Pelham, Perara, Pfaller, Pfaller, Pfaller, Pfaller, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pillar, Pollock, Pratje, Pratje, Randall, Randall, Raymond, Reid, Reid, Richter, Ricquier, Ridley, Rietveld, Riezman, Riezman, Riezman, Robinson, Roise, Roise, Rothblatt, Rothman, Runswick, Rödel, Römisch, Sabatini, Sachs, Sadler, Saraste, Schatz, Schlenstedt, Schleyer, Schleyer, Schleyer, Schmeizer, Schmidt, Schmidt, Schmidt, Schmidt, Schmidt, Schneller, Schwaiger, Schägger, Sebald, Shore, Sidhu, Sierra, Simmaco, Skerjank, Smagula, Stellwagen, Stuart, Suissa, Suissa, Surguchov, Suske, Sztul, Söllner, Takeda, Takeda, Takiguchi, Tamm, Taniuchi, Teintze, Tropschug, Tzagoloff, Tzagoloff, Ueda, Urban-Grimal, Van Loon, Van Loon, Van Loon, Van Loon, Van Loon, Van Loon, Van Loon, Van Loon, Van Steeg, Vasarotti, Vasarotti, Veloso, Velours, Verner, Vestweber, Viebrock, Von Heijne, Walter, Walter, Walter, Watanabe, Waters, Watts, Weiss, Werner, Wickner, Wiech, Wielburski, Wierenga, Witte, Wold, Woodrow, Wright, Wright, Wu, Yaffe, Yaffe, Yamane, Yoshida, Yoshida, Young, Zimmermann, Zimmermann, Zimmermann, Zimmermann, Zimmermann, Zimmermann, Zwizinski, Zwizinski, Zwizinski, Zwizinski +395 morecore +1 more sourceMitochondrial CircRNA CircMT‐RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair
Advanced Science, EarlyView.CircMT‐RNR2 promotes wound healing by enhancing fibroblast proliferation, migration, contraction, and extracellular matrix (ECM) production. It sustains mitochondrial redox balance by stabilizing the antioxidant protein PRDX3, thereby reducing ROS‐induced damage. In diabetic foot ulcers, hypoxia, hyperglycemia, and reduced FGF2 and EGF expression lower Guanglin Niu, Jennifer Geara, Yongjian Chen, Lihua Luo, Yanwei Xiao, Zhuang Liu, Margaux Gaborieau, Ling Pan, Edmund Loh, Dongqing Li, Pehr Sommar, Aoxue Wang, Xiaowei Zheng, Ning Xu Landén +13 morewiley +1 more sourceBCR::ABL1‐Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B‐ALL Cells to Enhancer‐Targeting Drugs
Advanced Science, EarlyView.Ng et al. show that the BCR::ABL1 kinase that drives the lymphoid leukemia Ph+B‐ALL modulates enhancer function by coopting signaling‐inducible transcription factors such as MYC, STAT5, and ETV5. BCR::ABL1 thereby promotes the transcriptional program driving and defining this leukemia and renders Ph+B‐ALL cells hypersensitive to enhancer‐inhibiting ...Han Leng Ng, Trudy Lee Glaser, Jintao Zhu, Mark E. Robinson, Kadriye N. Cosgun, Valeriya Malysheva, Ozgen Deniz, Nicholas T. Crump, Kaiyue Helian, Andrew J. Innes, Richard Burt, Li Sun, George John, Haibin Zhou, Atsunori Kaneshige, Longchuan Bai, Shaomeng Wang, Mikhail Spivakov, Markus Müschen, Niklas Feldhahn +19 morewiley +1 more sourceProtocol for automated analysis of biological images using Python code. [PDF]
STAR ProtocSacks B, Mody J, Huang Y, Jung S, Kimelman R, Eubanks E, Guadagno E, Cevallos J, Guntur A, Suvvari NR, Doshi A, Ravinutala N, Mosera A, Crimi A, Kara E. +14 moreeuropepmc +1 more source
