Results 81 to 90 of about 451,111 (312)

Matrix processing peptidase of mitochondria [PDF]

open access: yes, 1990
The mitochondrial processing peptidase (MPP) and the processing enhancing protein (PEP) cooperate in the proteolytic cleavage of matrix targeting sequences from nuclear-encoded mitochondrial precursor proteins.
Arretz, Michael   +3 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Assessment of genetically modified maize DP202216 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2019‐159)

open access: yesEFSA Journal
Genetically modified maize DP202216 was developed to confer tolerance to glufosinate‐ammonium‐containing herbicides and to provide an opportunity for yield enhancement under field conditions.
EFSA Panel on Genetically Modified Organisms (GMO)   +30 more
doaj   +1 more source

Antifolding activity of hsp60 couples protein import into the mitochondrial matrix with export to the intermembrane space [PDF]

open access: yes, 1992
Cytochrome b2 reaches the intermembrane space of mitochondria by transport into the matrix followed by export across the inner membrane. While in the matrix, the protein interacts with hsp60, which arrests its folding prior to export.
Guiard, Bernard   +6 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

EU support reductions would benefit California tomato growers and processors

open access: yesCalifornia Agriculture, 2006
Many countries apply import barriers for processing tomatoes, but the European Union is the main producer that uses export and production subsidies.
Bradley J. Rickard, Daniel Sumner
doaj   +2 more sources

Assessment of genetically modified soybean DBN9004 (application EFSA‐GMO‐BE‐2019‐165)

open access: yesEFSA Journal
Genetically modified soybean DBN9004 was developed to confer tolerance to glufosinate‐ammonium‐ and glyphosate‐containing herbicides. These properties were achieved by introducing the cp4 epsps and pat expression cassettes. The molecular characterisation
EFSA Panel on Genetically Modified Organisms (GMO)   +27 more
doaj   +1 more source

Economic Security of Russian Economy under the Conditions of Import Substitution Policy Implementation [PDF]

open access: yesЭкономика региона, 2015
In the article, the authors analyze the conditions of import substitution by types of activity from the perspective of the threat to the economic security of Russia. The factors of import substitution are presented.
Natalya Viktorovna Andreeva   +4 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

open access: yesAging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey   +12 more
wiley   +1 more source

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