Results 101 to 110 of about 2,675,626 (288)

Deep Importance Sampling

, 2020
We present a generic path-dependent importance sampling algorithm where the Girsanov induced change of probability on the path space is represented by a sequence of neural networks taking the past of the trajectory as an input. At each learning step, the neural networks' parameters are trained so as to reduce the variance of the Monte Carlo estimator ...
openaire   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

ANÁLISIS BAYESIANO DE ESTABILIDAD FENOTIPICA USANDO A PRIORI DE JEFFREYS BAYESIAN PHENOTYPIC STABILITY ANALYSIS USING JEFFREYS’S PRIOR

Revista Facultad Nacional de Agronomía Medellín, 2006
Uno de los métodos utilizados para evaluar estabilidad fenotípica es el propuesto por Shukla, el cual calcula la varianza de los genotipos dentro de la interacción genotipo por ambiente, para lo cual se hace uso de la estimación de los componentes de ...
José Miguel Cotes Torres, Adhemar Sanches   +1 more
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Inference for Two-Parameter Birnbaum–Saunders Distribution Based on Type-II Censored Data with Application to the Fatigue Life of Aluminum Coupon Cuts

Mathematics
This study addresses the problem of parameter estimation and prediction for type-II censored data from the two-parameter Birnbaum–Saunders (BS) distribution.
Omar M. Bdair
doaj   +1 more source

Magnetic-Map-Matching-Aided Pedestrian Navigation Using Outlier Mitigation Based on Multiple Sensors and Roughness Weighting

Sensors, 2019
This research proposes an algorithm that improves the position accuracy of indoor pedestrian dead reckoning, by compensating the position error with a magnetic field map-matching technique, using multiple magnetic sensors and an outlier mitigation ...
Yong Hun Kim, Min Jun Choi, Eung Ju Kim, Jin Woo Song   +3 more
doaj   +1 more source

Maximum Likelihood Estimation of Flexible Survival Densities with Importance Sampling. [PDF]

Proc Mach Learn Res, 2023
Ketenci M, Bhave S, Elhadad N, Perotte A.   +3 more
europepmc   +1 more source

Group Importance Sampling for Particle Filtering and MCMC

, 2018
Bayesian methods and their implementations by means of sophisticated Monte Carlo techniques have become very popular in signal processing over the last years.
Camps-Valls, G., Elvira, V., Martino, L.
core