Results 131 to 140 of about 2,675,626 (288)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Applied SciencesThis study presents a model-based parameter estimation method for integrating and validating uncertainty in expert knowledge and simulation models. The parameters of the models of complex systems are often unknown due to a lack of measurement data.
Éva Kenyeres, János Abonyi
doaj +1 more source
Constrained stochastic optimal control with learned importance sampling: A path integral approach. [PDF]
Int J Rob Res, 2022 Carius J +3 more
europepmc +1 more source
Importance sampling methods for Bayesian discrimination between embedded models
, 2009 This paper surveys some well-established approaches on the approximation of Bayes factors used in Bayesian model choice, mostly as covered in Chen et al. (2000).
Marin, Jean-Michel, Robert, Christian P.
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Novel blind identification and equalization new method based on particle filter
Tongxin xuebao, 2006 Based on particle filter theory,a new novel blind identification and equalization algorithm was proposed sam-pling of the posterior probability distribution was avoided by sampling the expectation instead of actual values of the channel,so as to reduce ...
WANG Lei, LIU Yu-lin
doaj
Vision-Assisted Probabilistic Inference of Milling Stability through Fully Bayesian Gaussian Process
MetalsThis paper presents a physics-free Bayesian approach for the learning and inference of probabilistic stability charts in milling operations. The approach does not require any information from machine tool structural dynamics or cutting force coefficients,
Vahid Ostad Ali Akbari +2 more
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source