Results 131 to 140 of about 2,663,721 (268)

Model-Centric Integration of Uncertain Expert Knowledge into Importance Sampling-Based Parameter Estimation

open access: yesApplied Sciences
This study presents a model-based parameter estimation method for integrating and validating uncertainty in expert knowledge and simulation models. The parameters of the models of complex systems are often unknown due to a lack of measurement data.
Éva Kenyeres, János Abonyi
doaj   +1 more source

Importance sampling methods for Bayesian discrimination between embedded models

open access: yes, 2009
This paper surveys some well-established approaches on the approximation of Bayes factors used in Bayesian model choice, mostly as covered in Chen et al. (2000).
Marin, Jean-Michel, Robert, Christian P.
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Novel blind identification and equalization new method based on particle filter

open access: yesTongxin xuebao, 2006
Based on particle filter theory,a new novel blind identification and equalization algorithm was proposed sam-pling of the posterior probability distribution was avoided by sampling the expectation instead of actual values of the channel,so as to reduce ...
WANG Lei, LIU Yu-lin
doaj  

Vision-Assisted Probabilistic Inference of Milling Stability through Fully Bayesian Gaussian Process

open access: yesMetals
This paper presents a physics-free Bayesian approach for the learning and inference of probabilistic stability charts in milling operations. The approach does not require any information from machine tool structural dynamics or cutting force coefficients,
Vahid Ostad Ali Akbari   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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