Results 241 to 250 of about 2,675,626 (288)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

First-Trimester Gestational Diabetes Mellitus Risk Prediction with Machine Learning Techniques: Results from the BORN2020 Cohort Study. [PDF]

J Clin Med
Pazaras N, Siargkas A, Tranidou A, Apostolopoulou A, Tsakiridis I, Bamidis PD, Stavros S, Potiris A, Chourdakis M, Dagklis T.   +9 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Interactions among weather and landscape affect Colorado potato beetle population dynamics. [PDF]

PLoS One
Cohen AL, Bradford B, Groves R, Szendrei Z.   +3 more
europepmc   +1 more source

Emphasizing Science: Black Pastors Encourage Awareness of Medical Information about COVID-19 Vaccine. [PDF]

Glob J Health Sci
Moore D, Caviness-Ashe N, Mansfield L, Onsomu EO.   +3 more
europepmc   +1 more source

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Improved Sampling‐Importance Resampling and Reduced Bias Importance Sampling

Scandinavian Journal of Statistics, 2003
Abstract. The sampling‐importance resampling (SIR) algorithm aims at drawing a random sample from a target distribution π. First, a sample is drawn from a proposal distributionq, and then from this a smaller sample is drawn with sample probabilities proportional to the importance ratios π/q.
Skare, Øivind, Bølviken, Erik, Holden, Lars   +2 more
openaire   +1 more source

The importance of importance sampling

Computing in Science & Engineering, 1999
Importance sampling is an underappreciated Monte Carlo technique. The authors have used it with great success. They share their insights. Importance sampling is designed to reduce the variance of the estimators for a given-size sample.
I. Beichl, F. Sullivan
openaire   +1 more source

Precomputed importance sampling

ACM SIGGRAPH 2008 posters, 2008
We present a method for cosine-weighted importance sampling of environment maps. Our technique has no runtime overhead. It is well suited for real-time ray tracing and for algorithms that generate only a few shadow rays per primary ray. Both memory consumption and preprocessing time are very low.
Manfred Ernst, Günther Greiner
openaire   +1 more source