Results 191 to 200 of about 31,688 (268)

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

Genomic epidemiology of <i>Mycobacterium tuberculosis</i> in Malawi: using global phylogeography to understand the impact of geographically focused interventions. [PDF]

Microb Genom
Beams AB, Song Y, McNichol J, Jones BR, Sobkowiak B, MacPherson P, Nliwasa M, Ndhlovu V, Phiri MD, Cohen T, Colijn C.   +10 more
europepmc   +1 more source

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, EarlyView.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source

US Antibiotic Importation and Supply Chain Vulnerabilities.

JAMA Health Forum
Socal MP, Sun Y, Ballreich JM, Lambert JD, Dai T, Dada M.   +5 more
europepmc   +1 more source

Inequitable access to medicines for neglected tropical diseases in Europe: health system vulnerabilities and a call for coordinated action. [PDF]

Lancet Reg Health Eur
Ravinetto R, Bottieau E, Fusco D, Marrone R, Van Den Broucke S, Tarrafeta-Sayas MB, Rinaldi L, Losada-Galván I, Calleri G, Albonico M.   +9 more
europepmc   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

Sortilin exhibits tumor suppressor-like activity by limiting EGFR transduction function. [PDF]

Oncogene
Lapeyronnie E, Granet C, Tricard J, Gallet F, Yassine M, Daverat H, Rovini A, Chermat A, Jauberteau MO, Bertin F, Melloni B, Vincent F, Naves T, Lalloué F.   +13 more
europepmc   +1 more source

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

Advanced Science, EarlyView.
Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan, Yongjie Huang, Jiabao Yang, Su Ma, Songsong Liu, Xuan Huang, Juergen Brosius, Huaping Zheng, Bing Yao, Li Chen, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Sustained increase in measles cases prompts the Americas to strengthen surveillance, rapid response and vaccination efforts. [PDF]

Rev Panam Salud Publica
Pan American Health Organization.
europepmc   +1 more source