Results 61 to 70 of about 212,518 (290)

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Clinical Features That Increase Suspicion of Brucella canis Infection in Dogs With Discospondylitis: A Multicenter Case–Control Study

Journal of Veterinary Internal Medicine
Background Brucella canis is an important cause of discospondylitis in dogs, and brucellosis can be challenging to diagnose. Early recognition could aid in early implementation of precautions to limit zoonotic transmission.
Courtney M. Moeller, Joseph W. Bartges, Kelsey D. Brust, Philip H. Kass, Rebecca F. Kelly, Erin W. Lashnits, Chai‐Fei Li, Lindsay K. Merkel, Jessica C. Pritchard, Jane E. Sykes   +9 more
doaj   +1 more source

Incidence of dengue virus infection among Japanese travellers, 2006 to 2010

Western Pacific Surveillance and Response, 2012
Introduction: Dengue continues to be a global public health concern. In Japan, although dengue cases are currently seen only among travellers returning from endemic areas, the number of reported cases is rising according to the national case-based ...
Yuki Tada, Tamano Matsui, Tomoe Shimada, Naomi Nakamura, Yuzo Arima, Nobuhiko Okabe   +5 more
doaj   +1 more source

Global dengue importation: a systematic review

BMC Infectious Diseases, 2021
Background Importation of dengue following globalization presents an emerging threat to global health. However, evidence on global geographical sources and the potential of dengue importation globally are lacking. This study aims to systematically review
Xiao Wei Sylvia Gwee, Pearleen Ee Yong Chua, Junxiong Pang   +2 more
doaj   +1 more source

Shrinking the Malaria Map: A Prospectus on Malaria Elimination [PDF]

, 2009
\ud Thirty-nine countries across the world are making progress toward malaria elimination. Some are committed to nationwide elimination, while others are pursuing spatially progressive elimination within their borders.
Feachem, Richard G.A., Phillips, Allison A., Targett, Geoff rey A.   +2 more
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cholera: Monitoring of Epidemiological Situation around the World and in Russia (2010–2019). Forecast for 2020

Проблемы особо опасных инфекций, 2020
Objective of the study was to monitor the spread of cholera in the world, in the CIS countries and in Russia with an assessment of risks and emergencies that contribute to the activation of the epidemic process.
E. A. Moskvitina, E. G. Yanovich, M. I. Kurilenko, V. D. Kruglikov, S. V. Titova, D. A. Levchenko, A. S. Vodop’yanov, A. A. Lopatin, S. M. Ivanova, B. M. Mishan’kin, A. S. Krivenko, G. B. Anisimova, A. K. Noskov   +12 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Epidemiologic Situation on Cholera in the World, CIS Countries and Russia. Prognosis

Проблемы особо опасных инфекций, 2010
Epidemiologic situation on cholera in the world, CIS countries and Russia has been evaluated for the period of 2000-2009. The last decade (2000-2009) is characterized by the on-going large epidemics and outbreaks of cholera in the countries of Africa and
Yu. M. Lomov, E. A. Moskvitina
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source