Results 71 to 80 of about 16,983,163 (288)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Comparison of the epidemiological aspects of acute infectious diseases between foreign and native imported cases in the border counties of Southwest China, 2008–2017

Epidemiology and Infection, 2019
This study analysed the epidemiological characteristics of imported cases of acute infectious diseases and compared these features by nationality in 25 border counties of Yunnan Province from 2008 to 2017 to inform prevention strategies.
Li Jiang, Tian Huang
semanticscholar   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Epidemic Trends of Imported Shigellosis Cases in Korea and Japan, 2016–2020

Hanggong uju uihakoeji, 2023
Purpose: To observe and compare the trends in epidemic aspects of imported shigellosis (Sg) cases from overseas travelers (OTs) in Korea and Japan between 2016 and 2020.
Won-Chang Lee, Myeon-Jin Lee, Kyu Sung Kim, Young Hwan Kwon   +3 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Epidemiological and entomological analysis of imported malaria in Pemba Island, Zanzibar: a study from 2020–2022

Malaria Journal
Background Since 2008, Zanzibar has significantly reduced the prevalence of malaria, keeping it at 1%. However, imported malaria particularly from mainland Tanzania continues to pose a major threat to sustaining these gains, especially on Pemba Island ...
Ali O. Ali, Ali M. Ali, Mwema Felix Mwema, Yeromin P. Mlacha   +3 more
doaj   +1 more source

Imported cases and minimum temperature drive dengue transmission in Guangzhou, China: evidence from ARIMAX model

Epidemiology and Infection, 2018
Dengue is the fastest spreading mosquito-transmitted disease in the world. In China, Guangzhou City is believed to be the most important epicenter of dengue outbreaks although the transmission patterns are still poorly understood.
Qinlong Jing, Qu Cheng, John M. Marshall, Wenbiao Hu, Z. C. Yang, Jiahai Lu   +5 more
semanticscholar   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

MELIOIDOSIS AND GLANDERS: CURRENT STATE AND ACTUAL ISSUES OF EPIDEMIOLOGICAL SURVEILLANCE

Журнал микробиологии, эпидемиологии и иммунобиологии, 2018
Burkholderia pseudomallei and Burkholderia mallei are etiologic agents of glanders and melioidosis, the particularly dangerous infections of animals and humans, and are attributed to potential agents of bioterrorism.
I. B. Zakharova, A. V. Toporkov, D. V. Viktorov   +2 more
doaj   +1 more source