Results 81 to 90 of about 4,591,150 (298)

Genomic surveillance reveals multiple origins and local transmission of travel-associated chikungunya virus in Yunnan, China

open access: yesBMC Microbiology
Background Chikungunya virus (CHIKV) is a mosquito-borne arbovirus causing debilitating arthralgia, posing a significant public health threat in Southeast Asia.
Mengyuan Zheng   +7 more
doaj   +1 more source

A combined strategy for screening a clustered mobile population returning from highly endemic areas for Plasmodium falciparum

open access: yesJournal of Infection in Developing Countries, 2017
Introduction: Early and accurate diagnosis of imported malaria cases in clusters is crucial for protecting the health of patients and local populations, especially confirmed parasitic persons who are asymptomatic. Methodology: A total of 226 gold miners
Mei Li   +5 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Imported melioidosis in Japan: a review of cases

open access: yes, 2018
Yoshiro Hadano Department of Infectious Diseases, St. Mary’s Hospital, Kurume, Fukuoka, Japan Abstract: Fourteen cases of reported melioidosis in Japan were reviewed. The mean age was 52.4 years (33–69 years), and all patients were male.
Hadano Y
core  

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs   +7 more
wiley   +1 more source

Demographic and clinical data of imported COVID-19 cases from Russia through the Suifenhe port.

open access: yes, 2021
Demographic and clinical data of imported COVID-19 cases from Russia through the Suifenhe port.
Kai Kang (195645)   +9 more
core   +1 more source

Artificial Intelligence‐Driven Extraction of Patient‐Reported Pain Outcomes in Osteoarthritis Using Large Language Models

open access: yesArthritis Care &Research, Accepted Article.
Objective Patient‐reported outcome measures (PROMs) are central to assessing symptom burden and treatment response in Osteoarthritis (OA) but are often embedded in unstructured clinical notes. We evaluated whether prompt‐engineered large language models (LLMs) could accurately extract or infer pain scores on a 0‐10 scale from routine OA clinical ...
Jainesh Doshi   +7 more
wiley   +1 more source

Dengue outbreaks in Taiwan, 1998-2017: Importation, serotype and temporal pattern

open access: yesAsian Pacific Journal of Tropical Medicine, 2018
Objective: To ascertain the role of imported cases and serotypes on dengue outbreaks in Taiwan which have been sporadic yet highly volatile during the past two decades, exhibiting record-breaking magnitude in recent years.
Ying-Hen Hsieh
doaj   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

open access: yesAdvanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio   +11 more
wiley   +1 more source

Modelled cases attributable to medical risk factors, recent transmission, and imported cases, 2001–2014.

open access: yes, 2019
In 2014, the major risk factors for TB were smoking (267 attributable cases), diabetes (162), ESRD (74), HIV (51), transplant (3) and TNF-alpha (1). Increased risk due to recent transmission accounted to 146 cases, and 80 cases were imported.
Andrew Hill (95939)   +10 more
core   +1 more source

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