Results 31 to 40 of about 112,057 (258)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Finding Impossible Differentials in ARX Ciphers under Weak Keys

IACR Transactions on Symmetric Cryptology
Impossible differential cryptanalysis is very important in the field of symmetric ciphers. Currently, there are many automatic search approaches to find impossible differentials.
Qing Ling, Tingting Cui, Hongtao Hu, Sijia Gong, Zijun He, Jiali Huang, Jia Xiao   +6 more
doaj   +1 more source

Cryptanalysis of Reduced round SKINNY Block Cipher

IACR Transactions on Symmetric Cryptology, 2018
SKINNY is a family of lightweight tweakable block ciphers designed to have the smallest hardware footprint. In this paper, we present zero-correlation linear approximations and the related-tweakey impossible differential characteristics for different ...
Sadegh Sadeghi, Tahereh Mohammadi, Nasour Bagheri   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

ToFA: Towards Fault Analysis of GIFT and GIFT-like Ciphers Leveraging Truncated Impossible Differentials

Transactions on Cryptographic Hardware and Embedded Systems
In this work, we introduce ToFA, the first fault attack (FA) strategy that attempts to leverage the classically well-known idea of impossible differential cryptanalysis to mount practically verifiable attacks on bit-oriented ciphers like GIFT and ...
Anup Kumar Kundu, Shibam Ghosh, Aikata Aikata, Dhiman Saha   +3 more
doaj   +1 more source

New Security Proofs and Complexity Records for Advanced Encryption Standard

IEEE Access, 2023
Common block ciphers like AES specified by the NIST or KASUMI (A5/3) of GSM are extensively utilized by billions of individuals globally to protect their privacy and maintain confidentiality in daily communications.
Orhun Kara
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source