Results 111 to 120 of about 649,205 (307)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Roof above the head : A qualitative assessment of rural housing in India [PDF]

open access: yes
The development of rural housing in a manner that results in adequate, quality shelter for inhabitants of Mahatma Gandhi’s “real India” is a challenge before the nation. What are the issues confronting rural housing development in India?
Bhide, Shashanka   +5 more
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Transfer Impression in Prosthodontics Implants for the Range of the Practitioner [PDF]

open access: yesPesquisa Brasileira em Odontopediatria e Clínica Integrada, 2006
Introduction: The success of an implant supported restoration is directly associated with accuracy and passive fit of fixture and abutments components, stability of implant/abutment interface, as well as adequate distribution of mastigatory loads to the ...
Érica Alves GOMES   +4 more
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Effect of retention features in custom trays on dimensional accuracy of master casts made from alginate impressions

open access: yesمجله دانشکده دندانپزشکی اصفهان, 2012
Introduction: Complete adhesion of the impression materials to trays is important to prevent impression materials from being pulled away from trays during removed from the mouth and to ensure that the direction of polymerization shrinkage will be towards
Ramin Mosharraf, Zeynab Zareie
doaj  

Finding Words: The Ligatus Glossary Project [PDF]

open access: yes, 2011
All crafts, trades and disciplines sooner or later develop their own specialist vocabularies to allow their practitioners to communicate quickly, easily and clearly when going about their everyday activities. In the more literate areas of life – medicine
Pickwoad, Nicholas
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Sensory emphasis on pork quality related to the diet content of fermentable fibre-rich feedstuffs (chicory and lupine) with special emphasis on the effect on boar taint [PDF]

open access: yes, 2007
Boar taint in entire male pork is caused by skatole and andros-tenone and other compounds such as indole. However, female pigs also pro-duce skatole and indole.
Byrne, Derek Victor   +2 more
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

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