Results 131 to 140 of about 95,960 (260)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Molecular dynamics simulation of polymerization kinetics, dimensional stability, and in silico toxicity of nextgeneration silicone impression materials in dentistry. [PDF]

J Mater Sci Mater Med
Saini RS, Dermawan D, Alshehri AHA, Binduhayyim RIH, Vyas R, Alshadidi AAF, Aldosari LIN, Kanji MA, Alarcón-Sánchez MA, Heboyan A.   +9 more
europepmc   +1 more source

Clinical evaluation of marginal fit of uncemented CAD-CAM monolithic zirconia three-unit restorations in anterior areas, using scannable and conventional polyvinyl siloxane impression materials. [PDF]

BMC Oral Health, 2023
Kalantari MH, Abbasi B, Giti R, Rastegar Z, Tavanafar S, Shahsavari-Pour S.   +5 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Evaluation of condensation silicone dental impression materials modified with diatomaceous Earth and zinc oxide fillers. [PDF]

Sci Rep
Fakoori M, Hesaraki S, Nezafati N, Ghiass M.   +3 more
europepmc   +1 more source

Effect of freshly placed core buildup composites on setting of silicon impression materials. [PDF]

J Indian Prosthodont Soc, 2021
Al-Rabab'ah MA, Hatamleh MM, Al-Tarawneh S, El-Ma'aita A, Tahun IA, Jalham IS.   +5 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Comparison of dental surface of canine teeth in dogs after crown preparation using CBCT-based surface reconstruction or conventional dental impression materials. [PDF]

Front Vet Sci
Metje B, Schreyer J, Lüpke M, Meller S, Klasen JRS, Gawor JP.   +5 more
europepmc   +1 more source

Evaluation of Antimicrobial Efficacy of UVC Radiation, Gaseous Ozone, and Liquid Chemicals Used for Disinfection of Silicone Dental Impression Materials. [PDF]

Materials (Basel), 2022
Wezgowiec J, Wieczynska A, Wieckiewicz M, Czarny A, Malysa A, Seweryn P, Zietek M, Paradowska-Stolarz A.   +7 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source