Results 131 to 140 of about 5,929,630 (303)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Comparative studies of accuracy for impression materials and die materials

, 1982
치의학과/석사[한글] 정착한 보철물의 제작을 위하여 인상재의 인기능력과 모형재의 재현능력을 정확히 알고 그 인상재에 가장 적합한 모형재를 선택하는 것은 매우 중요하다. 저자는 인상재와 모형재중 Alginate계 2종류, Polysulphide계 2종류, Silicone계 1종류 Polyethr계 1종류의 인상재와 M.C. Crystal Rock, New Plastone, Vel Mix, Die Keen의 모형재를 이용하였다. Steel M.
최치은
core  

Elasticity of Elastomer Impression Materials : Breaking Limit and Ultimate Strength

, 1974
A study of the breaking limit and ultimate strength of all elastomer impression materials in current use in Greece was made. Measurements were made at ten minutes, 24 hours, and 48 hours after mixing the material. Silicone and polyether materials showed
Thanos M. Kaloyannides
core   +1 more source

Evaluation and Comparison of the Dimensional Accuracy of Resultant Casts Made by Monophase Polyether and Monophase Addition Silicone Impression Materials − An In Vitro Study

Journal of Orofacial Sciences
Introduction: Dimensional accuracy when making impressions is crucial to the quality of fixed prosthodontics treatment, and impression materials are critical factors affecting this accuracy.
Raveena Makker, Vivek Choukse, Shilpi G Gupta, Rajeev Srivastava, Sourabh Khandelwal, Prashanthi Reddy   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Linear Dimensional Changes in Elastic Impression Materials

, 1980
Four classes of elastomeric impression materials (polysulfide, polyether, silicone, and agar-agar) were evaluated on the basis of linear dimensional stability as a function of time between taking and pouring an impression of mounted teeth.
R.A. Draughn, C.F. Marcinak, W.R. Flemming, F.A. Young   +3 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Objective Evaluation of Surface Microreplication by Dental Impression Materials

, 1978
Twenty-two materials, including 19 dental impression elastomers, were compared in their ability to replicate microscopic detail. Some polysulfide, silicone, and polyether materials performed well.
F.J. Schoen, H. Mohammed, R.E. Going, W. Fischlschweiger   +3 more
core   +1 more source

In Vitro Effect of Vent Size and Spacer Thickness on Pressure Produced during Maxillary Edentulous Impression Making by Different Impression Materials

Journal of Islamic Dental Association of Iran, 2016
Background and Aim: Inappropriate transfer of pressure during final impression making in fabrication of complete denture can result in ridge resorption.
Tahereh Imani Fouladi, Abbas Fallah Tafti, Mohammad Hoseain Lotfi Kamran, Reza Mostafapour, Majid Sadegh Pourshahab, Maryam Tajaddini   +5 more
doaj  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source