Results 11 to 20 of about 56,611 (265)

More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis

Frontiers in Immunology, 2020
Allergic bronchial asthma is a chronic disease of the airways that is characterized by symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute episodes of broncho-obstruction. This symptom-complex arises on the basis of
Andreas Frey, Andreas Frey, Lars P. Lunding, Lars P. Lunding, Johanna C. Ehlers, Johanna C. Ehlers, Markus Weckmann, Markus Weckmann, Ulrich M. Zissler, Ulrich M. Zissler, Michael Wegmann, Michael Wegmann   +11 more
doaj   +1 more source

Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors

Nature Communications, 2017
Altered genomic imprinting is frequently reported in cancer. Here, the authors analyze copy number and methylation in cancer cell lines and primary tumors to show that imprinted methylation profiles represent the accumulation of copy number alteration ...
Alex Martin-Trujillo, Enrique Vidal, Ana Monteagudo-Sánchez, Marta Sanchez-Delgado, Sebastian Moran, Jose Ramon Hernandez Mora, Holger Heyn, Miriam Guitart, Manel Esteller, David Monk   +9 more
doaj   +1 more source

Neurophysiological Mechanisms of Cow–Calf Bonding in Buffalo and Other Farm Animals

Animals, 2021
In buffaloes and other mammalian farm species, the mother provides food and protection to the young, but she is also the main source of behavioral and social learning for the offspring.
Agustín Orihuela, Daniel Mota-Rojas, Ana Strappini, Francesco Serrapica, Ada Braghieri, Patricia Mora-Medina, Fabio Napolitano   +6 more
doaj   +1 more source

A case of intraplacental gestational choriocarcinoma; characterised by the methylation pattern of the early placenta and an absence of driver mutations

BMC Cancer, 2019
Background Gestational choriocarcinoma is a rare malignancy believed to arise from the trophoblast cells of the placenta. Despite the frequently aggressive clinical nature, choriocarcinoma has been routinely curable with cytotoxic chemotherapy for over ...
Philip Savage, David Monk, Jose R. Hernandez Mora, Nick van der Westhuizen, Jennifer Rauw, Anna Tinker, Wendy Robinson, Qianqian Song, Michael J. Seckl, Rosemary A. Fisher   +9 more
doaj   +1 more source

Effect of Methane Inhibitors on Ruminal Microbiota During Early Life and Its Relationship With Ruminal Metabolism and Growth in Calves

Frontiers in Microbiology, 2021
The present study aimed to determine whether dietary supplementation with methanogen inhibitors during early life may lead to an imprint on the rumen microbial community and change the rumen function and performance of calves to 49-weeks of rearing ...
Omar Cristobal-Carballo, Omar Cristobal-Carballo, Susan A. McCoard, Adrian L. Cookson, Adrian L. Cookson, Siva Ganesh, Katherine Lowe, Richard A. Laven, Stefan Muetzel   +8 more
doaj   +1 more source

Imprinted Anti-Hemagglutinin and Anti-Neuraminidase Antibody Responses after Childhood Infections of A(H1N1) and A(H1N1)pdm09 Influenza Viruses

mBio, 2023
Immune imprinting is a driver known to shape the anti-hemagglutinin (HA) antibody landscape of individuals born within the same birth cohort. With the HA and neuraminidase (NA) proteins evolving at different rates under immune selection pressures, anti ...
Pavithra Daulagala, Brian R. Mann, Kathy Leung, Eric H. Y. Lau, Louise Yung, Ruipeng Lei, Sarea I. N. Nizami, Joseph T. Wu, Susan S. Chiu, Rodney S. Daniels, Nicholas C. Wu, David Wentworth, Malik Peiris, Hui-Ling Yen   +13 more
doaj   +1 more source

Sex dependent imprinting effects on complex traits in mice

BMC Evolutionary Biology, 2008
Background Genomic imprinting is an epigenetic source of variation in quantitative traits that results from monoallelic gene expression, where commonly either only the paternally- or the maternally-derived allele is expressed.
Leamy Larry J, Cheverud James M, Hager Reinmar, Wolf Jason B   +3 more
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Reassessment of weak parent-of-origin expression bias shows it rarely exists outside of known imprinted regions

eLife, 2023
In mouse and human, genes subjected to genomic imprinting have been shown to function in development, behavior, and post-natal adaptations. Failure to correctly imprint genes in human is associated with developmental syndromes, adaptive, and metabolic ...
Carol A Edwards, William MD Watkinson, Stephanie B Telerman, Lisa C Hulsmann, Russell S Hamilton, Anne C Ferguson-Smith   +5 more
doaj   +1 more source

The coevolution of sexual imprinting by males and females

Ecology and Evolution, 2016
Sexual imprinting is the learning of a mate preference by direct observation of the phenotype of another member of the population. Sexual imprinting can be paternal, maternal, or oblique if individuals learn to prefer the phenotypes of their fathers ...
Miguel Angel Gómez‐Llano, Eva María Navarro‐López, Robert Tucker Gilman   +2 more
doaj   +1 more source

Loss of Monoallelic Expression of IGF2 in the Adult Liver Via Alternative Promoter Usage and Chromatin Reorganization

Frontiers in Genetics, 2022
In mammals, genomic imprinting operates via gene silencing mechanisms. Although conservation of the imprinting mechanism at the H19/IGF2 locus has been generally described in pigs, tissue-specific imprinting at the transcript level, monoallelic-to ...
Jinsoo Ahn, Joonbum Lee, Joonbum Lee, Dong-Hwan Kim, In-Sul Hwang, In-Sul Hwang, Mi-Ryung Park, In-Cheol Cho, Seongsoo Hwang, Kichoon Lee, Kichoon Lee   +10 more
doaj   +1 more source