Results 101 to 110 of about 36,602 (286)

Graphene‐Interfaced Stretchable Sweat Patch for Multiplexed Electrochemical Monitoring of IL‐6, Glucose, and Calcium Ions

Advanced Materials Technologies, EarlyView.
Flexible sweat sensor patch integrating graphene‑interfaced gold microelectrodes functionalized with bio‑receptors and ion‑selective membrane, coupled with a capillary‑driven microfluidic layer and portable potentiostat electronics for multiplexed monitoring of inflammatory, metabolic, and electrolyte biomarkers in microliter sweat volumes.
Roomia Memon, Ali Tufani, Süleyman Çelik, Javed H. Niazi, Anjum Qureshi   +4 more
wiley   +1 more source

EMQN best practice guidelines for the molecular genetic testing and reporting of chromosome 11p15 imprinting disorders: Silver–Russell and Beckwith–Wiedemann syndrome [PDF]

, 2016
Molecular genetic testing for the 11p15-associated imprinting disorders Silver–Russell and Beckwith–Wiedemann syndrome (SRS, BWS) is challenging because of the molecular heterogeneity and complexity of the affected imprinted regions.
A Behnecke, A De Crescenzo, A Ibrahim, A Mussa, A Sparago, AC Smith, Andrea Riccio, B Keren, C Shuman, D Prawitt, David Monk, Deborah JG Mackay, Dirk Prawitt, DJ Mackay, DJ Mackay, E Meyer, Eamonn R Maher, EL Wakeling, Elizabeth Algar, F Brioude, F Brioude, F Brioude, Fiona Macdonald, Frédéric Brioude, G Binder, Gudrun Moore, H Bullman, HM Saal, Irène Netchine, J Beygo, J Bliek, Jet Bliek, JM Dupont, JM Kalish, Karen Grønskov, Karin Buiting, Katja Eggermann, KY Niederhoffer, L Cardarelli, L Tee, LE Docherty, Lukas Soellner, M Alders, M Begemann, M Begemann, M Constancia, M Elliott, M Kagami, Marcel Mannens, Matthias Begemann, MR DeBaun, P Monnier, Pablo Lapunzina, Paolo Lombardi, Rosanna Weksberg, S Azzi, S Azzi, S Bruce, S Kaltenbach, S Mulchandani, S Richards, S Schoenfelder, S Spengler, Silvia Russo, T Eggermann, T Eggermann, T Eggermann, T Eggermann, T Takenouchi, Thalia Antoniadi, Thomas Eggermann, Thomas Eggermann, Thomas Eggermann, Thomas Eggermann, W Abi Habib, WW Lam, X Cai, Y Ioannides, Zeynep Tümer   +78 more
core   +5 more sources

Enhancing Small Molecule Sensing With Aptameric Functionalized Nano Devices

Advanced Materials Technologies, EarlyView.
Unveiling an ultra‐sensitive, non‐invasive neurotransmitter sensor. For the first time, a nanoscale sensor for detecting an important neurotransmitter was demonstrated using micro‐electromechanical systems (MEMS) technology. Our approach utilized field‐effect transistor (FET)‐based readout to enable pico‐molar detection of biomarkers in sweat.
Thi Thanh Ha Nguyen, Cong Minh Nguyen, Quang Thang Trinh, Minh Anh Huynh, Khanh Vinh Ho, Dang Co Pham, Dzung Dao, Sven Ingebrandt, Sina Jamali, Xuan Thang Vu, Nam‐Trung Nguyen, Tuan‐Khoa Nguyen   +11 more
wiley   +1 more source

Non-genetic inheritance, fertility and assisted reproductive technologies [PDF]

, 2015
The concept of non-genetic inheritance is gaining considerable attention in the assisted reproductive technology (ART) community due to the reported differences between children born from ART and those that are conceived naturally.
Lane, M., Mc Pherson, N., Zander-Fox, D.
core   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Identification of genetic and non-genetic modifiers of genomic imprinting through screening of imprinted DMR methylation in humans

Epigenetics & Chromatin
Background Genomic imprinting is required for normal development, and abnormal methylation of differentially methylated regions (iDMRs) controlling the parent of origin-dependent expression of the imprinted genes has been found in congenital disorders ...
Francesco Cecere, Raissa Relator, Michael Levy, Ankit Verma, Haley McConkey, Bruno Hay Mele, Laura Pignata, Carlo Giaccari, Emilia D’Angelo, Subham Saha, Abu Saadat, Angela Sparago, Claudia Angelini, Flavia Cerrato, Bekim Sadikovic, Andrea Riccio   +15 more
doaj   +1 more source

Long contiguous stretches of homozygosity spanning shortly the imprinted loci are associated with intellectual disability, autism and/or epilepsy [PDF]

, 2015
BACKGROUND: Long contiguous stretches of homozygosity (LCSH) (regions/runs of homozygosity) are repeatedly detected by single-nucleotide polymorphism (SNP) chromosomal microarrays. Providing important clues regarding parental relatedness (consanguinity),
Ivan Y. Iourov, Maria A. Zelenova, Sergei A. Korostelev, Svetlana G. Vorsanova, Yuri B. Yurov   +4 more
core   +1 more source

An Artificial Antibody‐Based Toolbox Accelerates Validation of Hidden Microproteins Encoded by the Dark Genome

Advanced Science, EarlyView.
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He, Anqi Zhang, Zhanchen Guo, Qi Li, Song Gao, Wenyan Guan, Ying Li, Jingran Chen, Sijia Sun, Jian He, Zhen Liu   +10 more
wiley   +1 more source

Large-Scale Analysis of Loss of Imprinting in Human Pluripotent Stem Cells

Cell Reports, 2017
Summary: The parent-specific monoallelic expression of imprinted genes is controlled by DNA methylation marks that are established differentially in the germline.
Shiran Bar, Maya Schachter, Talia Eldar-Geva, Nissim Benvenisty   +3 more
doaj   +1 more source

Exploration of hydroxymethylation in Kagami-Ogata syndrome caused by hypermethylation of imprinting control regions [PDF]

, 2015
Primer sequences utilized in BS/oxBS pyrosequencing and cloning-based sequencing.
Kazuhiko Nakabayashi, Kazuki Yamazawa, Keiko Matsubara, Kenichiro Hata, Maki Fukami, Masayo Kagami, Tsutomu Ogata   +6 more
core   +2 more sources