Results 101 to 110 of about 18,499 (269)

Nanozymes for Advanced Hemoglobin‐Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond

Advanced Science, EarlyView.
This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka, Ana María Pablo‐Sainz‐Ezquerra, Eva Jakljevič, Niki Ktena, Leticia Hosta‐Rigau   +4 more
wiley   +1 more source

Sustainable Synaptic Device with Two‐Dimensional Ferroelectric Materials for Neuromorphic Computing

Advanced Science, EarlyView.
α‐In2Se3 based FeSFETs can be utilized as sustainable devices through polarization switching governed by both out‐of‐plane and in‐plane polarizations. Upon reaching a fatigued state, current annealing enabled by conductance modulation can significantly enhance the endurance of FeSFETs.
Jaewook Yoo, Seokjin Oh, Minah Park, Jong Min Song, Hongseung Lee, Seohyeon Park, Sojin Jung, Seongbin Lim, Soohyun Lim, Dongsun Shin, Ji Won Heo, TaeWan Kim, Hagyoul Bae   +12 more
wiley   +1 more source

Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader–Willi syndromes

, 2010
Angelman syndrome (AS) and Prader–Willi syndrome (PWS) are neurodevelopmental disorders of genomic imprinting. AS results from loss of function of the ubiquitin protein ligase E3A ( UBE3A ) gene, whereas the genetic ...
Khong Y. Ng, Stormy J. Chamberlain, Pin-Fang Chen, Fany Bourgois-Rocha, Marc Lalande, Fouad Lemtiri-Chlieh, Eric S. Levine   +6 more
core   +1 more source

Helicalization of Covalent Organic Framework Nanofibers with Amplified Spin Polarizability for Boosting Photocatalytic Hydrogen Evolution

Advanced Science, EarlyView.
A non‐covalent chirality‐induced strategy via chiral solvents is presented to synthesize helical 2D COF nanofibers with high crystallinity, high chirality, and high spin polarization. The helical structure enhances the concentration of photogenerated charges, suppresses exciton recombination, and extends carrier lifetimes, thereby significantly ...
Qi Zhong, Yongtu Tian, Yutao Sang, Changchun Wang, Jia Guo   +4 more
wiley   +1 more source

Mutations in NLRP5 are associated with reproductive wastage and multi-locus imprinting disorders in humans

Human imprinting disorders are congenital disorders of growth, development and metabolism, associated with disturbance of parent of origin-specific DNA methylation at imprinted loci across the genome.
DOCHERTY, LOUISE E, Buiting, Karin, Temple, Isabel, Kivuva, Emma, Eggermann, Thomas, Rezwan, Faisal I, Gizewska, Maria, Begemann, Matthias, Patalan, Michal, Hamilton-Shield, Julian P., Peregud-Pogorzelski, Jaroslaw, Baple, Emma, Turner, Claire L. S., Beygo, Jasmin, Mackay, Deborah, Mansour, Sahar, Soellner, Lukas, Smithson, Sarah F., Poole, Rebecca, Maher, Eamonn R, Horsthemke, Bernhard   +20 more
core   +1 more source

Genomic imprinting and human disease

, 2010
In many epigenetic phenomena, covalent modifications on DNA and chromatin mediate somatically heritable patterns of gene expression. Genomic imprinting is a classical example of epigenetic regulation in mammals.
Ryutaro Hirasawa, Robert Feil
core   +1 more source

Maternal variants in NLRP and other maternal effect proteins are associated with multilocus imprinting disturbance in offspring [PDF]

, 2018
Background: Genomic imprinting results from the resistance of germline epigenetic marks to reprogramming in the early embryo for a small number of mammalian genes.
Buiting, Karin, Baynam, Gareth, Thomas Eggermann, Turner, C.L.S, Franziska Degenhardt, Kolarova, Julia, Chi Dung, Vu, Chokkalingam, Kamal, Miriam Elbracht, Stephanie Kleinle, Kamal Chokkalingam, Maria Gizewska, Gareth Baynam, Turner, Claire L., González Fassrainer, Daniela, Bich Ngoc, C.T., Binder, Gerhard, Mackay, D.J.G., Vu Chi Dung, Temple, Isabel Karen, Kleinle, S., Siebert, Reiner, Mehta, Sarju G., Oehl-Jaschkowitz, Barbara, Degenhardt, Franziska, Deborah J G Mackay, Karin Buiting, Gerhard Binder, Beygo, J., Mackay, Deborah J.G., Docherty, L.E., Reiner Siebert, Christopher Schroeder, Turner, Claire L.S., Bich Ngoc, Can Thi, Eggermann, T., Kleinle, Stephanie, Claire L S Turner, Horton, Rachel, Begemann, M., Barbara Oehl-Jaschkowitz, Beygo, Jasmin, Sara Aljareh, Binder, G., Hamilton-Shield, J.P., Schroeder, C., Turner, Claire L. S., Wakeling, Emma L., Oehl-Jaschkowitz, B., Aljareh, Sara, Mackay, Deborah J G, Rezwan, F.I., Michal Patalan, Buiting, K., Patalan, M., Daniela González Fassrainer, Louise E Docherty, Gizewska, Maria, Mackay, Deborah J. G., Begemann, Matthias, Hamilton-Shield, Julian P., Mehta, Sarju G, Lokulo-Sodipe, Oluwakemi, Begemann, M. [et al] inc., Aljareh, S., Horton, R., Temple, I.K., Lokulo-Sodipe, O., Eggermann, Thomas, Ngoc, Can Thi Bich, Rezwan, Faisal I, Sarju G Mehta, Wakeling, E.L., Rezwan, Faisal I., Elbracht, Miriam, Chi Dung, V., Mehta, S.G., Docherty, Louise E, Kolarova, J., Elbracht, M., Baynam, G., Isabel Karen Temple, Degenhardt, F., Siebert, R., Julian P Hamilton-Shield, Jasmin Beygo, Patalan, Michal, González Fassrainer, D., Can Thi Bich Ngoc, Faisal I Rezwan, Matthias Begemann, Chokkalingam, K., Schroeder, Christopher, Dung, Vu Chi, Julia Kolarova, Emma L Wakeling, Wakeling, Emma L, Rachel Horton, Docherty, Louise E., Turner, Claire L S, Hamilton-shield, Julian P, Gizewska, M., Oluwakemi Lokulo-Sodipe   +102 more
core   +1 more source

Genomic imprinting disorders in humans: a mini-review [PDF]

Journal of Assisted Reproduction and Genetics, 2009
Mammals inherit two complete sets of chromosomes, one from the father and one from the mother, and most autosomal genes are expressed from both maternal and paternal alleles. Imprinted genes show expression from only one member of the gene pair (allele) and their expression are determined by the parent during production of the gametes.
openaire   +2 more sources

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

Advanced Science, EarlyView.
Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan, Yelian Yan, Yalin Liang, Kanghua Zhong, Zhican Fu, Xiaobo Wang, Chao Liu, Tao Huang, Keliang Wu   +8 more
wiley   +1 more source

DNA methylation analysis

Swiss Medical Weekly, 2013
DNA methylation, the addition of a methyl group to cytosines and adenosines, regulates gene expression on a level that is usually referred to as epigenetic, that is, stably maintained during cell divisions.
Thomas von Känel, Andreas R Huber
doaj   +1 more source