Results 101 to 110 of about 22,120,804 (300)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Farmers’ preferential choice decisions to alternative cassava value chain strands in Morogoro rural district, Tanzania [PDF]

The study was conducted to determine farmers’ preferential choice decision of alternative cassava value chain strands and as well as factors behind such decisions in Morogoro rural District, Tanzania. Factor analysis was first used to reduce and identify
Mdoe, N. Y. S., Sewando, Ponsian T., Mutabazi, K. D. S   +2 more
core  

Comparative Analysis of Conventional and Focused Data Augmentation Methods in Rib Fracture Detection in CT Images

Diagnostics
Background/Objectives: Rib fracture detection holds critical importance in the field of medical image processing. Methods: In this study, two different data augmentation methods, traditional data augmentation (Albumentations) and focused data ...
Mehmet Çağrı Göktekin, Evrim Gül, Feyza Aksu, Yeliz Gül, Metehan Özen, Yusuf Salik, Merve Kesim Önal, Engin Avci   +7 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Serum Levels of Irisin Are Positively Associated with Improved Cardiac Function in Patients with Heart Failure with Reduced Ejection Fraction

Biomedicines
Background: The purpose of the study is to investigate a possible predictive value of irisin for improved left ventricular (LV) ejection fraction (EF) in discharged patients with known heart failure with reduced ejection fraction (HFrEF).
Alexander E. Berezin, Tetiana A. Berezina, Evgen V. Novikov, Oleksandr O. Berezin   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Notes: George B. Lincoln, October 14, 1890

, 1890
Note about an article in the New York Tribune writing about letter written by George B ...
Lincoln, George B.
core  

Purdue Improved Crop Storage (PICS)

, 2018
The Purdue Improved Crop Storage (PICS) project provides a low-cost, simple, and effective technology for low-resource farmers to help them preserve their dry crops after harvest with minimal losses due to storage insects. PICS technology involves triple
Purdue Improved Crop Storage
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source