Results 111 to 120 of about 9,646,676 (303)
Objective Improvement in Information-Geometric Optimization [PDF]
, 2013 Information-Geometric Optimization (IGO) is a unified framework of stochastic algorithms for optimization problems. Given a family of probability distributions, IGO turns the original optimization problem into a new maximization problem on the parameter ...
Akimoto, Youhei, Ollivier, Yann
core +3 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
f-Divergence constrained policy improvement
, 2018 To ensure stability of learning, state-of-the-art generalized policy iteration algorithms augment the policy improvement step with a trust region constraint bounding the information loss.
Belousov, Boris, Peters, Jan
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Improving Emergency Department Performance Using Simulation
بیمارستان, 2014 Background: Emergency department performance can be evaluated in quantitative and qualitative criteria. Some quantitative criteria are considered such as length of stay, patient waiting time, the percentage of patients that treat in a specific time and ...
khodakaram Salimifard +2 more
doaj
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Concept of Human Rights Activity by Institutes of Civil Society Formation and Support by the State
Èkonomika, Pedagogika i Pravo, 2014 Author notes that in consciousness of the Russian citizens the belief in need of the strong state deeply took roots. The state mentality became a distinctive feature of the Russian mentality.
Ernest S. Aslanyan
doaj
Improvement of adhesive-bonded structural joints [PDF]
, 1970 Investigation is described of methods for obtaining uniform shear stress distribution in adhesives used in double-lap bonded joints. Design rules for reducing adhesive peak shear stresses are listed.
Evensen, H. A.
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
IMPROVING PERFORMANCE IMPROVEMENT [PDF]
The Annals of Family Medicine, 2017 openaire +3 more sources