Results 41 to 50 of about 83,728 (262)

Critical earthquake response of elastic-plastic structures under near-fault ground motions (Part 2: Forward-directivity input)

open access: yesFrontiers in Built Environment, 2015
The triple impulse input is used as a simplified version of the forward-directivity near-fault ground motion and a closed-form solution of the elastic-plastic response of a structure by this triple input is obtained.
Kotaro eKojima, Izuru eTakewaki
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Analysis of factors affecting dominant acoustic impulse-response frequency of orange fruit based on grey relative theory

open access: yes浙江大学学报. 农业与生命科学版, 2005
Using nondestructive acoustic impulse-response technique to evaluate the quality of oranges, it was found that there were lots of factors affecting dominant impulse-response frequency, such as mass, density, pH value, firmness and sugar content ...
HUANG Hui-ming   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Computing Impulse Response of Room Acoustics Using the Ray-Tracing Method in Time Domain

open access: yesArchives of Acoustics, 2013
This paper proposes a new approach for calculating the impulse response of room acoustics. Impulse response provides unique characterization of any discrete linear-time invariant (LTI) systems.
Adil ALPKOCAK, Malik Kemal SIS
doaj  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Critical response of a single-degree-of-freedom system with bilinear hysteresis and viscous damping under triple impulse

open access: yesFrontiers in Built Environment
A triple impulse is used as a mathematical model of forward-directivity inputs, which are fault-normal components of near-fault earthquake ground motions. In this paper, two types of the triple impulse input are employed.
Kotaro Kojima, Izuru Takewaki
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Algorithm of underdetermined convolutive blind source separation for high reverberation environment

open access: yesTongxin xuebao, 2023
To separate the underdetermined convolutive mixture signals in the high reverberation environment, a novel algorithm of underdetermined convolutive blind source separation was proposed.Aiming at the influence of high reverberation environment, a global ...
Yuan XIE   +3 more
doaj   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy