Results 51 to 60 of about 83,728 (262)

Structural Damage Identification with Extracted Impulse Response Functions and Optimal Sensor Locations

Electronic Journal of Structural Engineering, 2015
This paper presents a structural damage identification approach based on the time domain impulse response functions, which are extracted from the measured dynamic responses with the input available.
Jun Li, Hong Hao, XINGYU FAN
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Measurement of High-Power Microwave Impulse Response Characteristics of Reflector Materials

International Journal of Antennas and Propagation
High-power microwave (HPM) antenna, one of the key subsystems in the HPM system, is used for HPM radiation. Its performance is partly determined by the impulse responses of reflector materials under HPM.
Xianggang Hu, Jiancang Su, Mingtao Zhang, Jingang Gong, Kewei Cheng, Jia Liu, Jiande Zhang, Xiaoxin Zhu, Rui Li, Jie Cheng, Shaotong Wu   +10 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Adaptive Parameter Identification Based on Morlet Wavelet and Application in Gearbox Fault Feature Detection

EURASIP Journal on Advances in Signal Processing, 2010
Localized defects in rotating mechanical parts tend to result in impulse response in vibration signal, which contain important information about system dynamics being analyzed.
Wang Shibin, Zhu ZK, He Yingping, Huang Weiguo   +3 more
doaj  

An improved rotating HF signal injection method based on FIR filters for state estimation of BPMSM sensorless control

Advances in Mechanical Engineering, 2017
An improved rotating high-frequency signal injection method based on a finite impulse-response filter for state estimation of bearingless permanent magnet synchronous motor sensorless control is developed in this article.
Wei Ji, Guoding Shi, Bo Xu, Jian Xu
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Applications of Multifractals in the Analysis of Room Impulse Response - Initial Research [PDF]

Telfor Journal, 2011
The analysis of impulse response has a central place in room acoustics. The research presented in this paper was aimed at examining possibilities for applying multifractal theory in room acoustics focusing on the analysis of room impulse response ...
M. Pavlović, D. M. Ristić
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Surrogate impulse ground motion for practical simulation of critical nonlinear structural responses

Frontiers in Built Environment
Impulse-based representations of earthquake ground motions provide an efficient framework for evaluating critical nonlinear structural responses. However, the direct use of ideal impulse ground motions expressed by Dirac’s delta function may excite all ...
Hiroki Akehashi, Mao Kinoshita, Fumiya Ueno, Koji Yamato, Yusuke Ehara, Tatsuhiko Maeda   +5 more
doaj   +1 more source