Results 1 to 10 of about 10,783 (175)
E47 modulates hepatic glucocorticoid action [PDF]
Nature Communications, 2019 Glucocorticoids (GCs) are widely used anti-inflammatory drugs; however, long-term treatment causes metabolic side effects. Here, the authors show that E47 is a modulator of glucocorticoid receptor activity for a subset of target genes in mouse liver, and
M. Charlotte Hemmer +6 more
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E47 and Id1 interplay in epithelial-mesenchymal transition. [PDF]
PLoS ONE, 2013 E12/E47 proteins (encoded by E2A gene) are members of the class I basic helix-loop-helix (bHLH) transcription factors (also known as E proteins). E47 has been described as repressor of E-cadherin and inducer of epithelial-mesenchymal transition (EMT). We
Eva Cubillo +8 more
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Crystal structure of the minimalist Max-E47 protein chimera. [PDF]
PLoS ONE, 2012 Max-E47 is a protein chimera generated from the fusion of the DNA-binding basic region of Max and the dimerization region of E47, both members of the basic region/helix-loop-helix (bHLH) superfamily of transcription factors.
Faraz Ahmadpour +5 more
doaj +4 more sources
E47 upregulates ΔNp63α to promote growth of squamous cell carcinoma [PDF]
Cell Death and Disease, 2021 Targeted therapy has greatly improved both survival and prognosis of cancer patients. However, while therapeutic treatment of adenocarcinoma has been advanced greatly, progress in treatment of squamous cell carcinoma (SCC) has been slow and ineffective ...
Jing Xu +9 more
doaj +3 more sources
PTBP1 inhibition reprograms myogenesis to rescue impaired muscle regeneration in mdx mice through correcting E2A splicing [PDF]
Nature CommunicationsDuchenne muscular dystrophy, caused by mutations in the DMD gene encoding dystrophin, is a severe progressive muscle-wasting disorder characterized by impaired muscle regeneration.
Shusheng Fan +13 more
doaj +2 more sources
Evolved DNAzymes and Stable Activation Chemistry Enable High-Efficiency DNA Ligation. [PDF]
ChemistryIn vitro selection of pre‐structured DNA libraries and chemical screening of alternative activation groups yielded trans‐acting DNAzymes with faster ligation rates and enhanced DNA substrate stability. The combination of C3S1 DNAzymes and phosphobenzimidazole‐activated DNA substrates provides improved DNA ligation performance, offering promise for ...
Nurmi C, Mendonsa G, Bao M, Li Y.
europepmc +2 more sources
Frontiers in Endocrinology, 2023 PurposeE47 has been identified as a modulating transcription factor of glucocorticoid receptor target genes, its loss protecting mice from metabolic adverse effects of glucocorticoids.
Wei Zhang +10 more
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E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle‐specific gene transcription [PDF]
The EMBO Journal, 2005 Selective recognition of the E-box sequences on muscle gene promoters by heterodimers of myogenic basic helix-loop-helix (bHLH) transcription factors, such as MyoD, with the ubiquitous bHLH proteins E12 and E47 is a key event in skeletal myogenesis.
Frederic, Lluís +4 more
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Circulation Research, 2008 See related article, pages 624–634 The epidemic of obesity has become among the most serious health problems worldwide because the weight gain carries a high risk of developing life-threatening diseases such as type 2 diabetes, hypertension, coronary artery disease, and heart failure.
Kamal Rahmouni, Curt D. Sigmund
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Tasa de interés neutral y política monetaria para México, 2020-2024
El Trimestre Económico, 2021 Debido a la incertidumbre al respecto, en este artículo se analiza cuál podría ser la postura de política monetaria más adecuada para México: una que mantenga el objetivo de inflación sin afectar negativamente el crecimiento del producto.
Armando Sánchez Vargas +2 more
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