Results 1 to 10 of about 26,882 (189)

Redundant and additive functions of the four Lef/Tcf transcription factors in lung epithelial progenitors [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2020
In multicellular organisms, paralogs from gene duplication survive purifying selection by evolving tissue-specific expression and function. Whether this genetic redundancy is also selected for within a single cell type is unclear for multimember paralogs, as exemplified by the four obligatory Lef/Tcf transcription factors of ...
Jichao Chen, Akiyama Haruhiko, Chen Jichao   +2 more
exaly   +5 more sources

Long-read sequencing reveals increased isoform diversity in key transcription factor effectors of intercellular signalling at the invertebrate-vertebrate transition [PDF]

BMC Biology
Background Several intercellular signalling pathways (including wingless (Wnt), hedgehog (Hh), and bone morphogenetic protein (BMP)) are used repeatedly in animals throughout development and evolution and are also frequent targets for disease-associated ...
Nuria P. Torres-Aguila, Marika Salonna, Sebastian M. Shimeld, Stefan Hoppler, David E. K. Ferrier   +4 more
doaj   +2 more sources

Lysine Demethylase KDM2A Promotes Proteasomal Degradation of TCF/LEF Transcription Factors in a Neddylation-Dependent Manner

Cells, 2023
Canonical Wnt signaling is essential for a plethora of biological processes ranging from early embryogenesis to aging. Malfunctions of this crucial signaling pathway are associated with various developmental defects and diseases, including cancer ...
Tijana Šopin, František Liška, Tomáš Kučera, Dušan Cmarko, Tomáš Vacík   +4 more
doaj   +1 more source

The Wnt/β-catenin pathway regulates the expression of the miR-302 cluster in mouse ESCs and P19 cells. [PDF]

PLoS ONE, 2013
MicroRNAs of the miR-302 cluster are involved in early embryonic development and somatic cell reprogramming. Expression of the miR-302 gene is regulated by the binding of the pluripotency factors Oct4, Sox2 and Nanog to the miR-302 promoter. The specific
Christien Bräutigam, Angelo Raggioli, Jennifer Winter   +2 more
doaj   +1 more source

Distinct DNA binding sites contribute to the TCF transcriptional switch in C. elegans and Drosophila. [PDF]

PLoS Genetics, 2014
Regulation of gene expression by signaling pathways often occurs through a transcriptional switch, where the transcription factor responsible for signal-dependent gene activation represses the same targets in the absence of signaling.
Chandan Bhambhani, Aditi J Ravindranath, Remco A Mentink, Mikyung V Chang, Marco C Betist, Yaxuan X Yang, Sandhya P Koushika, Hendrik C Korswagen, Ken M Cadigan   +8 more
doaj   +1 more source

TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state

Cell Reports, 2021
Summary: Mouse embryonic stem cells (mESCs) can be maintained in vitro in defined N2B27 medium supplemented with two chemical inhibitors for GSK3 and MEK (2i) and the cytokine leukemia inhibitory factor (LIF), which act synergistically to promote self ...
Nikolaos Doumpas, Simon Söderholm, Smarth Narula, Steven Moreira, Bradley W. Doble, Claudio Cantù, Konrad Basler   +6 more
doaj   +1 more source

β-Catenin-independent activation of TCF1/LEF1 in human hematopoietic tumor cells through interaction with ATF2 transcription factors. [PDF]

PLoS Genetics, 2013
The role of Wnt signaling in embryonic development and stem cell maintenance is well established and aberrations leading to the constitutive up-regulation of this pathway are frequent in several types of human cancers.
Luca Grumolato, Guizhong Liu, Tomomi Haremaki, Sathish Kumar Mungamuri, Phyllus Mong, Gal Akiri, Pablo Lopez-Bergami, Adriana Arita, Youssef Anouar, Marek Mlodzik, Ze'ev A Ronai, Joshua Brody, Daniel C Weinstein, Stuart A Aaronson   +13 more
doaj   +1 more source

Wnt-mediated repression via bipartite DNA recognition by TCF in the Drosophila hematopoietic system. [PDF]

PLoS Genetics, 2014
The Wnt/β-catenin signaling pathway plays many important roles in animal development, tissue homeostasis and human disease. Transcription factors of the TCF family mediate many Wnt transcriptional responses, promoting signal-dependent activation or ...
Chen U Zhang, Timothy A Blauwkamp, Peter E Burby, Ken M Cadigan   +3 more
doaj   +1 more source

Biomarker potential of the LEF1/TCF family members in breast cancer: Bioinformatic investigation on expression and clinical significance

Genetics and Molecular Biology, 2023
The LEF1/TCF transcription factor family is related to the development of diverse tissue types, including the mammary tissue, and dysregulation of its expression and function has been described to favor breast tumorigenesis.
Beatriz Miotto Lima, Alexandre Luiz Korte de Azevedo, Igor Samesima Giner, Talita Helen Bombardelli Gomig, Enilze Maria de Souza Fonseca Ribeiro, Iglenir João Cavalli   +5 more
doaj   +1 more source

TCF/LEF Transcription Factors: An Update from the Internet Resources [PDF]

Cancers, 2016
T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) proteins (TCFs) from the High Mobility Group (HMG) box family act as the main downstream effectors of the Wnt signaling pathway. The mammalian TCF/LEF family comprises four nuclear factors designated TCF7, LEF1, TCF7L1, and TCF7L2 (also known as TCF1, LEF1, TCF3, and TCF4, respectively).
Hrčkulák, D. (Dušan), Kolář, M. (Michal), Strnad, H. (Hynek), Kořínek, V. (Vladimír)   +3 more
openaire   +3 more sources