Results 31 to 40 of about 26,882 (189)
PLoS Biology, 2019 The bipartite transcription factor β-catenin (β-cat)/T cell factor (TCF), formed by free β-cat and a given TCF family member, serves as the effector of the developmental Wnt signaling cascade.
Lili Tian +5 more
doaj +1 more source
The transcription factor TCF-1 enforces commitment to the innate lymphoid cell lineage [PDF]
Nature Immunology, 2019 Innate lymphoid cells (ILCs) play important functions in immunity and tissue homeostasis, but their development is poorly understood. Through the use of single-cell approaches, we examined the transcriptional and functional heterogeneity of ILC progenitors, and studied the precursor-product relationships that link the subsets identified.
Christelle Harly +9 more
openaire +4 more sources
Cancer Cell International, 2019 Background Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck region with poorly understood progression and prognosis. The present study aims at exploring whether the expression of β-catenin, TCF-4, and survivin affects ...
Pei-Ying Jin +7 more
doaj +1 more source
The transcriptional factor Tcf-4 contains different binding sites for β-catenin and plakoglobin. [PDF]
Journal of Biological Chemistry, 2002 beta-Catenin and plakoglobin are two related armadillo proteins necessary for the establishment of adhesion junctions and desmosomes. Moreover, beta-catenin can also act as a transcriptional co-activator through its interaction with the members of Tcf/LEF-1 transcriptional factor family. We show here that Tcf-4 can be phosphorylated in vitro by protein
Susana, Miravet +5 more
openaire +4 more sources
eLife, 2022 Serum response factor (SRF) is an essential transcription factor that influences many cellular processes including cell proliferation, migration, and differentiation.
Colin J Dinsmore, Philippe Soriano
doaj +1 more source
β-Catenin and TCFs/LEF signaling discordantly regulate IL-6 expression in astrocytes
Cell Communication and Signaling, 2020 Background The Wnt/β-catenin signaling pathway is a prolific regulator of cell-to-cell communication and gene expression. Canonical Wnt/β-catenin signaling involves partnering of β-catenin with members of the TCF/LEF family of transcription factors (TCF1,
KaReisha F. Robinson +4 more
doaj +1 more source
Cell Reports, 2023 Summary: The blood-brain barrier (BBB) is primarily manifested by a variety of physiological properties of brain endothelial cells (ECs), but the molecular foundation for these properties remains incompletely clear.
Min Yu +15 more
doaj +1 more source
An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP
eLife, 2015 TCF/LEF factors are ancient context-dependent enhancer-binding proteins that are activated by β-catenin following Wnt signaling. They control embryonic development and adult stem cell compartments, and their dysregulation often causes cancer.
Marc Fiedler +5 more
doaj +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
All Tcf HMG box transcription factors interact with Groucho-related co-repressors [PDF]
Nucleic Acids Research, 2001 Tcf/Lef family transcription factors are the downstream effectors of the Wingless/Wnt signal transduction pathway. Upon Wingless/Wnt signalling, beta-catenin translocates to the nucleus, interacts with Tcf (1-3) and thus activates transcription of target genes (4,5).
Brantjes, H. +3 more
openaire +3 more sources