Molecular characterization of a zebrafish TCF ETS-domain transcription factor [PDF]
Oncogene, 1999 The ternary complex factor (TCF) subfamily of ETS-transcription factors represent key nuclear targets of the MAP kinase pathways. Members of this subfamily are classified by the presence of several conserved domains for DNA binding, interaction with SRF, interaction with MAP kinases and transcriptional activation.
Brown LA +4 more
openaire +4 more sources
Role of TCF/LEF Transcription Factors in Bone Development and Osteogenesis [PDF]
International Journal of Medical Sciences, 2018 Bone formation occurs by two distinct mechanisms, namely, periosteal ossification and endochondral ossification. In both mechanisms, osteoblasts play an important role in the secretion and mineralization of bone-specific extracellular matrix. Differentiation and maturation of osteoblasts is a prerequisite to bone formation and is regulated by many ...
Li, Zhengqiang +5 more
openaire +2 more sources
MafB, WDR77, and ß-catenin interact with each other and have similar genome association profiles.
PLoS ONE, 2022 MafB (a bZIP transcription factor), ß-catenin (the ultimate target of the Wnt signal transduction pathway that acts as a transcriptional co-activator of LEF/TCF proteins), and WDR77 (a transcriptional co-activator of multiple hormone receptors) are ...
Lizhi He +4 more
doaj +1 more source
SOX transcription factors direct TCF-independent WNT/beta-catenin transcription [PDF]
, 2021 ABSTRACT WNT/ß-catenin signaling regulates gene expression across numerous biological contexts including development, stem cell homeostasis and tissue regeneration, and dysregulation of this pathway has been implicated in many diseases including cancer. One fundamental question is how distinct WNT target genes are activated in a context-
Shreyasi Mukherjee +3 more
openaire +1 more source
The LEF-1 high-mobility group box adopts residual structure in its DNA-free form
Journal of Magnetic Resonance Open, 2022 Intrinsically disordered regions (IDRs) lack stable tertiary structure and instead rapidly interconvert between different conformations. This structural plasticity enables IDRs to act as key players in cellular signaling pathways.
T. Reid Alderson +3 more
doaj +1 more source
Inhibition of Tcf-4 induces apoptosis and enhances chemosensitivity of colon cancer cells. [PDF]
PLoS ONE, 2012 Aberrant activation of β-catenin/Tcf-4 signaling has been implicated in human carcinogenesis, including colorectal cancer. In this study, we compared the effects of Tcf-4 knockdown with β-catenin knockdown on cell proliferation, apoptosis, and ...
Jiang Xie +7 more
doaj +1 more source
Human FasL gene is a target of β-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions. [PDF]
PLoS ONE, 2011 FasL expression on human immune cells and cancer cells plays important roles in immune homeostasis and in cancer development. Our previous study suggests that polymorphisms in the FasL promoter can significantly affect the gene expression in human cells.
Jianming Wu +9 more
doaj +1 more source
Wnt/β-catenin signaling pathway is a direct enhancer of thyroid transcription factor-1 in human papillary thyroid carcinoma cells. [PDF]
PLoS ONE, 2011 The Wnt/β-catenin signaling pathway is involved in the normal development of thyroid gland, but its disregulation provokes the appearance of several types of cancers, including papillary thyroid carcinomas (PTC) which are the most common thyroid tumours.
Marie Gilbert-Sirieix +6 more
doaj +1 more source
Atypical Transcriptional Activation by TCF via a Zic Transcription Factor in C. elegans Neuronal Precursors [PDF]
Developmental Cell, 2015 Transcription factors of the TCF family are key mediators of the Wnt/β-catenin pathway. TCF usually activates transcription on cis-regulatory elements containing TCF binding sites when the pathway is active and represses transcription when the pathway is inactive.
Murgan, S. +6 more
openaire +3 more sources
Frontiers in Cell and Developmental Biology, 2021 Since its first discovery in the late 90s, Wnt canonical signaling has been demonstrated to affect a large variety of neural developmental processes, including, but not limited to, embryonic axis formation, neural proliferation, fate determination, and ...
Johnny Bou-Rouphael, Béatrice C. Durand
doaj +1 more source