Myeloid Translocation Gene Family Members Associate with T-Cell Factors (TCFs) and Influence TCF-Dependent Transcription [PDF]
Molecular and Cellular Biology, 2008 Canonical Wnt signaling is mediated by a molecular "switch" that regulates the transcriptional properties of the T-cell factor (TCF) family of DNA-binding proteins. Members of the myeloid translocation gene (MTG) family of transcriptional corepressors are frequently disrupted by chromosomal translocations in acute myeloid leukemia, whereas MTG16 may be
Amy C, Moore +9 more
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Frontiers in Immunology, 2019 The long-term persistence of viral antigens drives virus-specific CD8 T cell exhaustion during chronic viral infection. Yet exhausted, CD8 T cells are still endowed with certain levels of effector function, by which they can keep viral replication in ...
Yifei Wang +17 more
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The intestine-specific transcription factor Cdx2 inhibits β-catenin/TCF transcriptional activity by disrupting the β-catenin–TCF protein complex [PDF]
Carcinogenesis, 2009 Cdx2 is an intestine-specific transcription factor known to regulate proliferation and differentiation. We have reported previously that Cdx2 limits the proliferation of human colon cancer cells by inhibiting the transcriptional activity of the beta-catenin-T-cell factor (TCF) bipartite complex. Herein we further elucidate this mechanism.
Rong-Jun, Guo +4 more
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TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms
JACC: Basic to Translational Science, 2023 Summary: Phenotypic switching of vascular smooth muscle cells is a central process in abdominal aortic aneurysm (AAA) pathology. We found that knockdown TCF7L1 (transcription factor 7-like 1), a member of the TCF/LEF (T cell factor/lymphoid enhancer ...
Jing Wang, MM +7 more
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Subfunctionalization and neofunctionalization of vertebrate Lef/Tcf transcription factors
Developmental Biology, 2012 Invertebrates express a multitude of Wnt ligands and all Wnt/β-catenin signaling pathways converge to only one nuclear Lef/Tcf. In vertebrates, however, four distinct Lef/Tcfs, i.e. Tcf-1, Lef, Tcf-3, and Tcf-4 fulfill this function. At present, it is largely unknown to what extent the various Lef/Tcfs are functionally similar or diversified in ...
Klingel, Susanne +5 more
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Structure-function analysis of the C-clamp of TCF/Pangolin in Wnt/ß-catenin signaling. [PDF]
PLoS ONE, 2014 The evolutionarily conserved Wnt/ß-catenin (Wnt/ß-cat) pathway plays an important role in animal development in metazoans. Many Wnt targets are regulated by members of the TCF/LEF1 (TCF) family of transcription factors.
Aditi J Ravindranath, Ken M Cadigan
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Differential binding of Lef1 and Msx1/2 transcription factors to Dkk1 CNEs correlates with reporter gene expression in vivo. [PDF]
PLoS ONE, 2014 Besides the active Wnt signalling itself, the extracellular inhibition by Dkk1 is important for various embryonic developmental processes, such as optic vesicle differentiation and facial outgrowth.
Oliver Lieven +3 more
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eLife, 2020 Lineage specification is governed by gene regulatory networks (GRNs) that integrate the activity of signaling effectors and transcription factors (TFs) on enhancers.
Shreyasi Mukherjee +11 more
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Hepatic expression of glutamine synthetase in rats is controlled by STAT5 and TCF transcription factors† [PDF]
Hepatology, 2006 In mammalian liver, high glutamine synthetase (GS) expression is restricted to hepatocytes surrounding the terminal venules. The most important enhancer of the GS gene is located approximately 2520 base pairs (bp) upstream from the transcriptional start point. The nature of the transcription factors that bind to the enhancers has remained enigmatic. In
Max, Werth +2 more
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Regulation of TCF ETS-domain transcription factors by helix-loop-helix motifs [PDF]
Nucleic Acids Research, 2003 DNA binding by the ternary complex factor (TCF) subfamily of ETS-domain transcription factors is tightly regulated by intramolecular and intermolecular interactions. The helix-loop-helix (HLH)-containing Id proteins are trans-acting negative regulators of DNA binding by the TCFs.
Stinson J +5 more
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