Results 51 to 60 of about 26,882 (189)

Ragomics‐Meta: An open‐source, scalable, reproducible, and extensible multi‐omics analysis workflow

iMetaOmics, EarlyView.
Ragomics‐Meta is an open‐source, scalable, and reproducible multi‐omics workflow for metabolism‐centered analysis (https://www.raganetwork.com/). It integrates scRNA/snRNA‐seq, spatial transcriptomics, scATAC‐seq, and metabolomics modules to support quality control, dimensionality reduction, clustering, differential expression and accessibility ...
Zeping Gui, Huidong Su, Yuhao Chen, Jixing Yuan, Yexiu Gao, Ze Yu, Jing Zhang, Qingyi Zhu, Min Gu, Mulong Du, Zijie Wang, Ming Chen   +11 more
wiley   +1 more source

Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function

Cell Reports, 2021
Summary: Transcription factors harbor defined regulatory intrinsically disordered regions (IDRs), which raises the question of how they mediate binding to structured co-regulators and modulate their activity.
Benjamin Bourgeois, Tianshu Gui, Diana Hoogeboom, Henry G. Hocking, Gesa Richter, Emil Spreitzer, Martin Viertler, Klaus Richter, Tobias Madl, Boudewijn M.T. Burgering   +9 more
doaj   +1 more source

The plant microbiome: From ecological foundations to precision microbial engineering for sustainable agriculture

iMeta, EarlyView.
From ecological principles to precision engineering of plant microbiomes for sustainable agriculture. The plant holobiont integrates diverse microbial niches (including rhizosphere, endosphere, phyllosphere, seed, and aerial‐root mucilagesphere), host genetics (namely M genes), and host metabolites. Furthermore, molecular dialogues, including rhizobial
Mi Wei, Tengxiang Lian, Liying Chen, Lanxiang Wang, Junjie Ye, Xiaofang Yao, Shilong Duan, Ziyu Lu, Jinji Tu, Hongfu Li, Xin‐Yue Xu, Jie Zhou, Junliang He, Feiying Zhu, Paola Bonfante, Lam‐Son Phan Tran, Zhiqiang Pang, Xin Zhou, Zhihui Xu, Lin Zhang, Mengcen Wang, Xiaolin Wang, Chang‐Fu Tian, Yong‐Xin Liu, Kai Sun, Ertao Wang, Xianan Xie   +26 more
wiley   +1 more source

pVHL regulates protein stability of the TCF/LEF transcription factor family via ubiquitin-independent proteasomal degradation

Cellular and Molecular Life Sciences
The Wnt/β-catenin signaling pathway plays key roles in development and adult tissue homeostasis by controlling cell proliferation and cell fate decisions.
Caixia Wang, Xiaozhi Rong, Haifeng Zhang, Bo Wang, Yan Bai, Yonghua Sun, Chengtian Zhao, Jianfeng Zhou   +7 more
doaj   +1 more source

Hyperglycemia Altered the Fate of Cardiac Stem Cells to Adipogenesis through Inhibiting the β-Catenin/TCF-4 Pathway

Cellular Physiology and Biochemistry, 2018
Background/Aims: Hyperglycemia is an important risk factor for the most severe cardiovascular diseases in patients with diabetes. It has been demonstrated that cardiac stem cells (CSCs) play a pivotal role in the maintenance of cardiac homeostasis and ...
Xiaoming Zhang, Ke Meng, Yujie Pu, Chao Wang, Yingying Chen, Linlin Wang   +5 more
doaj   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Deciphering the Innate Lymphoid Cell Transcriptional Program

Cell Reports, 2016
Innate lymphoid cells (ILCs) are enriched at mucosal surfaces, where they provide immune surveillance. All ILC subsets develop from a common progenitor that gives rise to pre-committed progenitors for each of the ILC lineages.
Cyril Seillet, Lisa A. Mielke, Daniela B. Amann-Zalcenstein, Shian Su, Jerry Gao, Francisca F. Almeida, Wei Shi, Matthew E. Ritchie, Shalin H. Naik, Nicholas D. Huntington, Sebastian Carotta, Gabrielle T. Belz   +11 more
doaj   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Wnt target genes and where to find them [version 1; referees: 3 approved]

F1000Research, 2017
Wnt/β-catenin signaling is highly conserved throughout metazoans, is required for numerous essential events in development, and serves as a stem cell niche signal in many contexts. Misregulation of the pathway is linked to several human pathologies, most
Aravinda-Bharathi Ramakrishnan, Ken M. Cadigan   +1 more
doaj   +1 more source

Bipartite recognition of DNA by TCF/Pangolin is remarkably flexible and contributes to transcriptional responsiveness and tissue specificity of wingless signaling. [PDF]

PLoS Genetics, 2014
The T-cell factor (TCF) family of transcription factors are major mediators of Wnt/β-catenin signaling in metazoans. All TCFs contain a High Mobility Group (HMG) domain that possesses specific DNA binding activity. In addition, many TCFs contain a second
Hilary C Archbold, Chris Broussard, Mikyung V Chang, Ken M Cadigan   +3 more
doaj   +1 more source