Results 61 to 70 of about 5,592,241 (297)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source
Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito +8 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Paramagnetic rim lesions (PRLs) and choroid plexus (CP) enlargement reflect smoldering inflammation in multiple sclerosis. Their role in cognitive progression remains unexplored. Eighty‐seven early relapsing–remitting MS patients were enrolled at diagnosis and followed longitudinally.
Stefano Ziccardi +15 more
wiley +1 more source
Effects of Electrical Stimulation with Different Impulses on Physical Characteristics of Rabbit Meat
Animal Production: Indonesian Journal of Animal Production, 2010 Meat becoming less tender with age. One of the methods to increase the meat tenderness is by electrical simulation. The objective of this study was to investigate the effect of electrical simulation with different level of impulses on physical ...
H Yurmiati, GA Wiedy, S Kusmajadi
doaj
Seasonal Influences on the Impulse Characteristics of Grounding Systems for Tropical Countries
Energies, 2019 One of the most important parameters of the performance of grounding systems is the soil resistivity. As generally known, the soil resistivity changes seasonally, hence the performance of grounding systems, at DC and under high impulse conditions.
Muhd Shahirad Reffin +6 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes +75 more
wiley +1 more source
Characteristics analysis of muzzle impulse noise based on wavelet energy spectrum
Journal of Measurement Science and Instrumentation, 2015 Because muzzle impulse noise could cause damage to or have an influence on the operator,the effective protective measures should be taken.Therefore,correct analysis of impulse noise characteristics is very significant.Considering the shortcomings of fast
LAI Fu-wen +3 more
doaj
Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane +10 more
wiley +1 more source
Research on Characteristics of Directional Impulse Sound Sources in a U-shape Connected Well [PDF]
E3S Web of ConferencesThe traditional U-shaped connected well connection technology mainly relies on the magnetic steering technology to guide the connection of the two wells, but the magnetic steering technology has the disadvantage of short detection distance.
Zhang Jing, Zhang Peng
doaj +1 more source