Results 51 to 60 of about 67,041 (267)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Study on Spatial-Temporal Distribution Characteristics of the Discharge Process in a 1 m Rod-Plate Gap Under Different Polarity Lightning Impulses

IEEE Access, 2019
The observation of the air gap discharge process is the basis of revealing the physical mechanism of gas discharge and establishing the accurate numerical simulation model.
Yaqi Zhang, Yongxia Han, Wenbo Zheng, Jie Yang, Lu Qu, Gang Liu, Xiangen Zhao, Licheng Li   +7 more
doaj   +1 more source

Characteristics of Impulse Discharges in Wet Soil

The Transactions of The Korean Institute of Electrical Engineers, 2017
This paper presents the experimental results related to soil ionization and electrical breakdown in a concentric hemispherical electrode system under lightning impulse voltages. Dynamic voltage-current and impedance-time characteristics of soil ionization were measured and analyzed. Also the electrical breakdowns of the soil gap were investigated.
Hoe-Gu Kim, Bok-Hee Lee
openaire   +2 more sources

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Effects of Electrical Stimulation with Different Impulses on Physical Characteristics of Rabbit Meat

Animal Production: Indonesian Journal of Animal Production, 2010
Meat becoming less tender with age. One of the methods to increase the meat tenderness is by electrical simulation. The objective of this study was to investigate the effect of electrical simulation with different level of impulses on physical ...
H Yurmiati, GA Wiedy, S Kusmajadi
doaj  

Seasonal Influences on the Impulse Characteristics of Grounding Systems for Tropical Countries

Energies, 2019
One of the most important parameters of the performance of grounding systems is the soil resistivity. As generally known, the soil resistivity changes seasonally, hence the performance of grounding systems, at DC and under high impulse conditions.
Muhd Shahirad Reffin, Abdul Wali Abdul Ali, Normiza Mohamad Nor, Nurul Nadia Ahmad, Syarifah Amanina Syed Abdullah, Azwan Mahmud, Farhan Hanaffi   +6 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Characteristics analysis of muzzle impulse noise based on wavelet energy spectrum

Journal of Measurement Science and Instrumentation, 2015
Because muzzle impulse noise could cause damage to or have an influence on the operator,the effective protective measures should be taken.Therefore,correct analysis of impulse noise characteristics is very significant.Considering the shortcomings of fast
LAI Fu-wen, ZHANG Jian-yu, HU Gui-mei, Key Laboratory of Instrumentation Science & Dynamic Measurement   +3 more
doaj  

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Research on Characteristics of Directional Impulse Sound Sources in a U-shape Connected Well [PDF]

E3S Web of Conferences
The traditional U-shaped connected well connection technology mainly relies on the magnetic steering technology to guide the connection of the two wells, but the magnetic steering technology has the disadvantage of short detection distance.
Zhang Jing, Zhang Peng
doaj   +1 more source