Results 71 to 80 of about 5,592,241 (297)

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Experimental Investigation of Impulsive Coupling Characteristics of Asteroid Simulants Based on Laser Ablation Propulsion

Aerospace
The ablation impulse of typical asteroid simulants irradiated by a nanosecond pulsed laser has been investigated in a vacuum environment. A torsional pendulum measurement system was constructed to calculate the impulse of laser ablation.
Yingjie Ma, Hao Chang, Weijing Zhou, Zhilong Jian   +3 more
doaj   +1 more source

Inference for Impulse Responses [PDF]

Poor identification of individual impulse response coefficients does not necessarily mean that an impulse response is imprecisely estimated. This paper introduces a three-pronged approach on how to communicate uncertainty of impulse response estimates ...
Oscar Jorda
core  

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Low rank prior in single patches for non-pointwise impulse noise removal [PDF]

, 2015
This paper introduces a low rank prior in small oriented noise-free image patches: Considering an oriented patch as a matrix, a low-rank matrix approximation is enough to preserve the texture details in the optimally oriented patch.
Trucco, Emanuele; id_orcid, Pakleppa, Markus, Wang, Ruixuan   +2 more
core   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

Model-Free Impulse Responses [PDF]

This paper introduces methods for computing impulse response functions that do not require specification and estimation of the unknown dynamic multivariate system itself.
Oscar Jorda
core   +2 more sources

Surrogate impulse ground motion for practical simulation of critical nonlinear structural responses

Frontiers in Built Environment
Impulse-based representations of earthquake ground motions provide an efficient framework for evaluating critical nonlinear structural responses. However, the direct use of ideal impulse ground motions expressed by Dirac’s delta function may excite all ...
Hiroki Akehashi, Mao Kinoshita, Fumiya Ueno, Koji Yamato, Yusuke Ehara, Tatsuhiko Maeda   +5 more
doaj   +1 more source

Nationwide Survey of Association Between Fever and Epileptic Seizure in CDKL5 Deficiency Disorder Revealed Therapeutic Implications

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang, Jialin Du, Jinghui Liu, Dongmei Hu, Hongxin Wang, Xiaoxiao Man, Lehong Gao, Shimin Hu, Xianghong Meng, Hongyang Zhao, Minjing Hu, Yingxue Yang, Zhiqi Xiong, Liankun Ren   +13 more
wiley   +1 more source

Feature Extraction of Weak Fault for Rolling Bearing based on Spectral Kurtosis and MOMEDA

Jixie chuandong, 2021
Aiming at the problem that the early periodic transient impulse of rolling bearings is not obvious and the spectral kurtosis is poorly analyzed under low signal-to-noise ratio， a method of extracting the weak fault features of rolling bearing based on ...
Fuwang Liang, Huer Sun, Kexin Liu
doaj